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Prepublished online as a Blood First Edition Paper on September 5, 2002; DOI 10.1182/blood-2002-03-0744. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-03-0744v1 101/3/970    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hsu, S.-C. Articles by Lai, M.-Z. Search for Related Content PubMed PubMed Citation Articles by Hsu, S.-C. Articles by Lai, M.-Z. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2003, Vol. 101, No. 3, pp. 970-976 IMMUNOBIOLOGY Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development Shu-Ching Hsu, Chia-Cheng Wu, Jiahuai Han, and Ming-Zong Lai From the Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China; Graduate Institute of Immunology, National Taiwan University School of Medicine, Taipei, Taiwan, Republic of China; Department of Immunology, Scripps Research Institute, La Jolla, CA; and Graduate Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, Republic of China. Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)-activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal-regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p38 MAPK impaired CD4CD8 thymocyte development and T-cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that, in addition to early thymocyte development, p38 is involved in positive selection. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Liu, J.-f. Wu, Y.-y. Zhan, H.-z. Chen, X.-y. Zhang, and Q. Wu Regulation of the Orphan Receptor TR3 Nuclear Functions by c-Jun N Terminal Kinase Phosphorylation Endocrinology, January 1, 2007; 148(1): 34 - 44. [Abstract] [Full Text] [PDF] A. L. Miller, M. S. Webb, A. J. Copik, Y. Wang, B. H. Johnson, R. Kumar, and E. B. Thompson p38 Mitogen-Activated Protein Kinase (MAPK) Is a Key Mediator in Glucocorticoid-Induced Apoptosis of Lymphoid Cells: Correlation between p38 MAPK Activation and Site-Specific Phosphorylation of the Human Glucocorticoid Receptor at Serine 211 Mol. Endocrinol., June 1, 2005; 19(6): 1569 - 1583. [Abstract] [Full Text] [PDF] J. M. Kim, J. M. White, A. S. Shaw, and B. P. Sleckman MAPK p38{alpha} Is Dispensable for Lymphocyte Development and Proliferation J. Immunol., February 1, 2005; 174(3): 1239 - 1244. [Abstract] [Full Text] [PDF] C.-C. Wu, S.-C. Hsu, H.-m. Shih, and M.-Z. Lai Nuclear Factor of Activated T Cells c Is a Target of p38 Mitogen-Activated Protein Kinase in T Cells Mol. Cell. Biol., September 15, 2003; 23(18): 6442 - 6454. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020