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Prepublished online as a Blood First Edition Paper on October 17, 2002; DOI 10.1182/blood-2002-05-1426.
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Blood, 1 March 2003, Vol. 101, No. 5, pp. 1977-1980
NEOPLASIA
Brief report
All-trans-retinoic acid induces CD52 expression in
acute promyelocytic leukemia
Shi-Wu Li,
Dongqi Tang,
Kim P. Ahrens,
Jin-Xiong She,
Raul C. Braylan, and
Lijun Yang
From the Department of Pathology, Immunology, and
Laboratory Medicine, University of Florida College of Medicine,
Gainesville.
It is well known that all-trans-retinoic acid (ATRA)
can induce myeloid cell differentiation in acute promyelocytic leukemia (APL) cells. In this study, we found that ATRA treatment of the APL
cell line NB4 induced the expression of CD52, both at transcriptional and translational levels. CD52 is a 21- to 28-kDa nonmodulating cell
surface glycosylphosphatidylinositol-linked glycoprotein expressed on
lymphocytes and monocytes, but not in human myeloid cells. The
ATRA-dependent induction of CD52 expression was not observed in
non-promyelocytic leukemia cell lines such as K562, U937, and HL-60,
suggesting that induction of CD52 by ATRA may be specific to leukemic
cells that express promyelocytic leukemia-retinoic acid receptor
 (PML-RAR) or are at the promyelocytic stage of myeloid
development. Antibodies against CD52 are used therapeutically against
lymphocytes in certain leukemias and in patients undergoing transplantation. An ATRA-induced high level of CD52 expression might
potentially serve as a novel therapeutic target in treatment of APL.
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