SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on November 21, 2002; DOI 10.1182/blood-2002-07-2216. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-07-2216v1 101/7/2464    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Franco, V. Articles by Iannitto, E. Search for Related Content PubMed PubMed Citation Articles by Franco, V. Articles by Iannitto, E. Related Collections Neoplasia Review Articles Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2003, Vol. 101, No. 7, pp. 2464-2472 REVIEW ARTICLE Splenic marginal zone lymphoma Vito Franco, Ada Maria Florena, and Emilio Iannitto From the Istituto di Anatomia e Istologia Patologica and Divisione di Ematologia con TMO, University of Palermo, Palermo, Italy. Splenic marginal zone lymphoma (SMZL) is a specific low-grade small B-cell lymphoma that is incorporated in the World Health Organization classification. Characteristic features are splenomegaly, moderate lymphocytosis with villous morphology, intrasinusoidal pattern of involvement of various organs, especially bone marrow, and relative indolent course. Tumor progression with increase of blastic forms and aggressive behavior are observed in a minority of patients. Molecular and cytogenetic studies have shown heterogeneous results probably because of the lack of standardized diagnostic criteria. To date, no definitive therapy has been established. Therapeutic options include treatment abstention, splenectomy, splenic irradiation, and chemotherapy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. KALPADAKIS, G. A. PANGALIS, E. DIMITRIADOU, M. K. ANGELOPOULOU, M. P. SIAKANTARIS, M.-C. KYRTSONIS, M. XIMERIS, T. TZENOU, S. SAHANAS, X. YIAKOUMIS, et al. Mutation Analysis of IgVH Genes in Splenic Marginal Zone Lymphomas: Correlation with Clinical Characteristics and Outcome Anticancer Res, May 1, 2009; 29(5): 1811 - 1816. [Abstract] [Full Text] [PDF] M. Okuda, N. Tanaka, M. Kashio, N. Sagara, K. Aozasa, Y. Okuda, and I. Tsuyuguchi Rapid improvement of massive bloody pleural effusion after splenectomy for splenic marginal zone lymphoma BMJ Case Reports, April 14, 2009; 2009(apr07_2): bcr0920080974 - bcr0920080974. [Abstract] [Full Text] K N Naresh, I Lampert, R Hasserjian, D Lykidis, K Elderfield, D Horncastle, N Smith, W Murray-Brown, and G W Stamp Optimal processing of bone marrow trephine biopsy: the Hammersmith Protocol. J. Clin. Pathol., September 1, 2006; 59(9): 903 - 911. [Abstract] [Full Text] [PDF] L. Arcaini, M. Lazzarino, N. Colombo, S. Burcheri, E. Boveri, M. Paulli, E. Morra, M. Gambacorta, S. Cortelazzo, A. Tucci, et al. Splenic marginal zone lymphoma: a prognostic model for clinical use Blood, June 15, 2006; 107(12): 4643 - 4649. [Abstract] [Full Text] [PDF] P.-h. Tu, C. Giannini, A. R. Judkins, J. M. Schwalb, R. Burack, B. P. O'Neill, A. T. Yachnis, P. C. Burger, B. W. Scheithauer, and A. Perry Clinicopathologic and Genetic Profile of Intracranial Marginal Zone Lymphoma: A Primary Low-Grade CNS Lymphoma That Mimics Meningioma J. Clin. Oncol., August 20, 2005; 23(24): 5718 - 5727. [Abstract] [Full Text] [PDF] M. Carbonari, E. Caprini, T. Tedesco, F. Mazzetta, V. Tocco, M. Casato, G. Russo, and M. Fiorilli Hepatitis C Virus Drives the Unconstrained Monoclonal Expansion of VH1-69-Expressing Memory B Cells in Type II Cryoglobulinemia: A Model of Infection-Driven Lymphomagenesis J. Immunol., May 15, 2005; 174(10): 6532 - 6539. [Abstract] [Full Text] [PDF] S. de Sanjose, A. Dickie, T. Alvaro, V. Romagosa, M. Garcia Villanueva, E. Domingo-Domenech, A. Fernandez de Sevilla, and E. El-Omar Helicobacter pylori and Malignant Lymphoma in Spain Cancer Epidemiol. Biomarkers Prev., June 1, 2004; 13(6): 944 - 948. [Abstract] [Full Text] [PDF] M. Batten, C. Fletcher, L. G. Ng, J. Groom, J. Wheway, Y. Laabi, X. Xin, P. Schneider, J. Tschopp, C. R. Mackay, et al. TNF Deficiency Fails to Protect BAFF Transgenic Mice against Autoimmunity and Reveals a Predisposition to B Cell Lymphoma J. Immunol., January 15, 2004; 172(2): 812 - 822. [Abstract] [Full Text] [PDF] S. A. Pileri, P. L. Zinzani, P. Went, A. Pileri Jr, and M. Bendandi Indolent lymphoma: the pathologist's viewpoint Ann. Onc., January 1, 2004; 15(1): 12 - 18. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020