|
|
Prepublished online as a Blood First Edition Paper on December 5, 2002; DOI 10.1182/blood-2002-10-3065.
 Previous Article | Table of Contents | Next Article 
Blood, 1 April 2003, Vol. 101, No. 7, pp. 2514-2520
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
B7-H1 is up-regulated in HIV infection and is a novel surrogate
marker of disease progression
Daria Trabattoni,
Marina Saresella,
Mara Biasin,
Adriano Boasso,
Luca Piacentini,
Pasquale Ferrante,
Haidong Dong,
Renato Maserati,
Gene M. Shearer,
Lieping Chen, and
Mario Clerici
From the Chairs of Immunology and Virology,
Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie
Avanzate (DISP LITA) Vialba, University of Milano, Milano,
Italy; Department of Biology, Don C. Gnocchi Foundation, Istituto di
Ricerca e Cura a Carattere Scientifico (IRCCS), Milano, Italy;
Experimental Immunology Branch (EIB), National Cancer Institute,
National Institutes of Health, Bethesda, MD; Department of Immunology,
Mayo Clinic, Rochester, MN; and Infectious Diseases Clinic, IRCCS San
Matteo, Pavia, Italy.
The ligation of programmed death-ligand 1 (B7-H1) to T cells
results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV
infection, a disease characterized by increased IL-10 production, by
measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed
that (1) B7-H1 expression and mRNA are augmented in cells of HIV
patients; (2) increased IL-10 production in these patients is
largely induced by B7-H1-expressing CD14+ cells; (3) an
inverse correlation is detected between B7-H1 expression and CD4
counts, whereas the up-regulation of B7-H1 is directly associated with
HIV plasma viremia; (4) antiviral therapy results in the parallel down
modulation of IL-10 production and B7-H1 expression/synthesis; and (5)
B7-H1/CD80 and B7-H1/CD86 mRNA ratios are increased in peripheral blood
mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1
synthesis and expression are up-regulated in HIV infection, and the
degree of dysregulation correlates with the severity of disease.
Aberrant antigen presentation by antigen-presenting cells (APCs) that
exhibit increased B7-H1 expression and IL-10 production in HIV
infection could be responsible for T-lymphocyte unresponsiveness and
loss of protective immunity. B7-H1 is a surrogate marker potentially
involved in AIDS disease progression.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. E. Campbell, N. B. Tustin, E. Riedel, R. Tustin III, J. Taylor, J. Murray, and S. D. Douglas
Cryopreservation Decreases Receptor PD-1 and Ligand PD-L1 Coinhibitory Expression on Peripheral Blood Mononuclear Cell-Derived T Cells and Monocytes
Clin. Vaccine Immunol.,
November 1, 2009;
16(11):
1648 - 1653.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Brockman, D. S. Kwon, D. P. Tighe, D. F. Pavlik, P. C. Rosato, J. Sela, F. Porichis, S. Le Gall, M. T. Waring, K. Moss, et al.
IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells
Blood,
July 9, 2009;
114(2):
346 - 356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. E. Kaufmann and B. D. Walker
PD-1 and CTLA-4 Inhibitory Cosignaling Pathways in HIV Infection and the Potential for Therapeutic Intervention
J. Immunol.,
May 15, 2009;
182(10):
5891 - 5897.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Oestreich, H. Yoon, R. Ahmed, and J. M. Boss
NFATc1 Regulates PD-1 Expression upon T Cell Activation
J. Immunol.,
October 1, 2008;
181(7):
4832 - 4839.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Mozaffarian, A. E. Wiedeman, and A. M. Stevens
Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1
Rheumatology,
September 1, 2008;
47(9):
1335 - 1341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. Jeong, Y.-J. Lee, S.-K. Seo, S.-W. Lee, S.-J. Park, J.-N. Lee, H.-S. Sohn, S. Yao, L. Chen, and I. Choi
Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection
J. Leukoc. Biol.,
March 1, 2008;
83(3):
755 - 764.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Okazaki and T. Honjo
PD-1 and PD-1 ligands: from discovery to clinical application
Int. Immunol.,
July 2, 2007;
(2007)
dxm057v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Tsushima, S. Yao, T. Shin, A. Flies, S. Flies, H. Xu, K. Tamada, D. M. Pardoll, and L. Chen
Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy
Blood,
July 1, 2007;
110(1):
180 - 185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Su
PD-1+ T cells: exhausted and premature?
Blood,
June 1, 2007;
109(11):
4593 - 4594.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-Y. Zhang, Z. Zhang, X. Wang, J.-L. Fu, J. Yao, Y. Jiao, L. Chen, H. Zhang, J. Wei, L. Jin, et al.
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors
Blood,
June 1, 2007;
109(11):
4671 - 4678.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Chen, Z. Zhang, W. Chen, Z. Zhang, Y. Li, M. Shi, J. Zhang, L. Chen, S. Wang, and F.-S. Wang
B7-H1 Up-Regulation on Myeloid Dendritic Cells Significantly Suppresses T Cell Immune Function in Patients with Chronic Hepatitis B
J. Immunol.,
May 15, 2007;
178(10):
6634 - 6641.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Freeman, E. J. Wherry, R. Ahmed, and A. H. Sharpe
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade
J. Exp. Med.,
October 2, 2006;
203(10):
2223 - 2227.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. K. Kim, H. Guan, G. Zu, H. Li, L. Wu, X. Feng, C. Elmets, Y. Fu, and H. Xu
High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals
J. Leukoc. Biol.,
April 1, 2006;
79(4):
686 - 695.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. W. Vahlenkamp, M. B. Tompkins, and W. A. F. Tompkins
Feline Immunodeficiency Virus Infection Phenotypically and Functionally Activates Immunosuppressive CD4+CD25+ T Regulatory Cells
J. Immunol.,
April 15, 2004;
172(8):
4752 - 4761.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
