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Prepublished online as a Blood First Edition Paper on December 5, 2002; DOI 10.1182/blood-2002-10-3065. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-10-3065v1 101/7/2514    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Trabattoni, D. Articles by Clerici, M. Search for Related Content PubMed PubMed Citation Articles by Trabattoni, D. Articles by Clerici, M. Related Collections Clinical Trials and Observations Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2003, Vol. 101, No. 7, pp. 2514-2520 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression Daria Trabattoni, Marina Saresella, Mara Biasin, Adriano Boasso, Luca Piacentini, Pasquale Ferrante, Haidong Dong, Renato Maserati, Gene M. Shearer, Lieping Chen, and Mario Clerici From the Chairs of Immunology and Virology, Dipartimento Scienze Precliniche Laboratorio Integrato Tecnologie Avanzate (DISP LITA) Vialba, University of Milano, Milano, Italy; Department of Biology, Don C. Gnocchi Foundation, Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS), Milano, Italy; Experimental Immunology Branch (EIB), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Immunology, Mayo Clinic, Rochester, MN; and Infectious Diseases Clinic, IRCCS San Matteo, Pavia, Italy. The ligation of programmed death-ligand 1 (B7-H1) to T cells results in the preferential production of interleukin 10 (IL-10). We investigated if B7-H1 would be up-regulated in HIV infection, a disease characterized by increased IL-10 production, by measuring B7-H1, B7-1 (CD80), and B7-2 (CD86) expression and mRNA in 36 HIV-infected patients and in 22 healthy controls (HCs). Results showed that (1) B7-H1 expression and mRNA are augmented in cells of HIV patients; (2) increased IL-10 production in these patients is largely induced by B7-H1-expressing CD14+ cells; (3) an inverse correlation is detected between B7-H1 expression and CD4 counts, whereas the up-regulation of B7-H1 is directly associated with HIV plasma viremia; (4) antiviral therapy results in the parallel down modulation of IL-10 production and B7-H1 expression/synthesis; and (5) B7-H1/CD80 and B7-H1/CD86 mRNA ratios are increased in peripheral blood mononuclear cells (PBMCs) of HIV patients compared with HCs. B7-H1 synthesis and expression are up-regulated in HIV infection, and the degree of dysregulation correlates with the severity of disease. Aberrant antigen presentation by antigen-presenting cells (APCs) that exhibit increased B7-H1 expression and IL-10 production in HIV infection could be responsible for T-lymphocyte unresponsiveness and loss of protective immunity. B7-H1 is a surrogate marker potentially involved in AIDS disease progression. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H.-Y. Jeong, Y.-J. Lee, S.-K. Seo, S.-W. Lee, S.-J. Park, J.-N. Lee, H.-S. Sohn, S. Yao, L. Chen, and I. Choi Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection J. Leukoc. Biol., March 1, 2008; 83(3): 755 - 764. [Abstract] [Full Text] [PDF] T. Okazaki and T. Honjo PD-1 and PD-1 ligands: from discovery to clinical application Int. Immunol., July 2, 2007; (2007) dxm057v1. [Abstract] [Full Text] [PDF] F. Tsushima, S. Yao, T. Shin, A. Flies, S. Flies, H. Xu, K. Tamada, D. M. Pardoll, and L. Chen Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy Blood, July 1, 2007; 110(1): 180 - 185. [Abstract] [Full Text] [PDF] L. 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