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Prepublished online as a Blood First Edition Paper on November 21, 2002; DOI 10.1182/blood-2002-07-2215. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-07-2215v1 101/7/2756    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Copie-Bergman, C. Articles by Leroy, K. Search for Related Content PubMed PubMed Citation Articles by Copie-Bergman, C. Articles by Leroy, K. Related Collections Neoplasia Signal Transduction Gene Expression Genomics Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2003, Vol. 101, No. 7, pp. 2756-2761 NEOPLASIA Interleukin 4-induced gene 1 is activated in primary mediastinal large B-cell lymphoma Christiane Copie-Bergman, Marie-Laure Boulland, Catherine Dehoulle, Peter Möller, Jean-Pierre Farcet, Martin J. S. Dyer, Corinne Haioun, Paul-Henri Roméo, Philippe Gaulard, and Karen Leroy From the Département de Pathologie, the Service d'Immunologie Biologique, and the Service d'Hématologie Clinique, EA2348, AP-HP, Hôpital Henri Mondor, Créteil, France; the Institute of Pathology, University of Ulm, Germany; the Department of Pathology, University of Leicester, United Kingdom; and the Département d'Hématologie of Institut Cochin, Maternité Port-Royal, Paris, France. The molecular markers that distinguish primary mediastinal large B-cell lymphoma (PMBL) from nonmediastinal diffuse large B-cell lymphomas (NM-DLBLs) remain to be identified. Using cDNA representational difference analysis to compare PMBL and NM-DLBL transcripts, we isolated a cDNA fragment homologous to the mouse B-cell interleukin 4 (IL-4)-inducible gene FIG1 (interleukin 4-induced gene 1) transcript. The human FIG1 mRNA encodes a 567 amino acid protein that comprises a signal peptide and a large flavin-binding amino oxidase domain, and shares significant homology with secreted apoptosis-inducing L-amino acid oxidases. Northern blot studies showed that FIG1 mRNA expression is mainly restricted to lymphoid tissues. It is expressed at low levels in thymus, spleen, tonsils, and reactive lymph nodes, and is highly up-regulated in IL-4+CD40-activated tonsillar B cells. Interestingly, in human B-cell lines, FIG1 mRNA expression appeared restricted to the PMBL-derived MedB-1 and Karpas 1106 cell lines. Using real-time reverse transcriptase-polymerase chain reaction (RT-PCR), we demonstrated that all but one PMBL (16/17) displayed high FIG1 mRNA levels, whereas most NM-DLBLs (12/18) and all low-grade B-cell lymphomas tested (8/8) exhibited low FIG1 mRNA levels. The difference between PMBLs and NM-DLBLs was statistically significant (Fisher test; P = .0003). Southern blot studies did not show rearrangement of the FIG1 gene. FIG1 gene expression might be due to a constitutive activation of a cytokine signaling pathway in PMBL. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. H. Cho, S. Goenka, T. Henttinen, P. Gudapati, A. Reinikainen, C. M. Eischen, R. Lahesmaa, and M. 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