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Prepublished online as a Blood First Edition Paper on December 12, 2002; DOI 10.1182/blood-2002-09-2876. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-09-2876v1 101/8/3052    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fehniger, T. A. Articles by Caligiuri, M. A. Search for Related Content PubMed PubMed Citation Articles by Fehniger, T. A. Articles by Caligiuri, M. A. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 April 2003, Vol. 101, No. 8, pp. 3052-3057 IMMUNOBIOLOGY CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity Todd A. Fehniger, Megan A. Cooper, Gerard J. Nuovo, Marina Cella, Fabio Facchetti, Marco Colonna, and Michael A. Caligiuri From the Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, OH; the Department of Veterinary Biosciences, The Ohio State University, Columbus, OH; the Department of Pathology, The Ohio State University, Columbus, OH; the Comprehensive Cancer Center, The Ohio State University, Columbus, OH; the Department of Internal Medicine, Washington University, St Louis, MO; the Department of Pathology and Immunology, Washington University, St Louis, MO; and the Istituto di Anatomia Patologica, Universita di Brescia, Spedali Civili di Brescia, Brescia, Italy. Natural killer (NK) cells are innate lymphocytes that provide cytokines critical for early host defense against pathogens. One subset of human NK cells (CD56bright) constitutively expresses the high-affinity interleukin 2 (IL-2) receptor and produces immunoregulatory cytokines. Here, we demonstrate that CD56bright NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinity IL-2 receptor, costimulates CD56bright NK cells to secrete IFN-. Thus, adaptive immunoregulators influence innate cytokine production, which in turn may influence the developing antigen-specific immune response. These data show a dynamic interaction between innate and adaptive human lymphocytes and emphasize the importance of studying interactions between immune components to understand the immune response as a whole. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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