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Prepublished online as a Blood First Edition Paper on January 9, 2003; DOI 10.1182/blood-2002-10-3071. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-10-3071v1 101/9/3359    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cook, J. D. Articles by Skikne, B. S. Search for Related Content PubMed PubMed Citation Articles by Cook, J. D. Articles by Skikne, B. S. Related Collections Red Cells Plenary Papers Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 May 2003, Vol. 101, No. 9, pp. 3359-3363 PLENARY PAPER The quantitative assessment of body iron James D. Cook, Carol H. Flowers, and Barry S. Skikne From the Department of Medicine, Kansas University Medical Center, Kansas City, KS. Current initiatives to reduce the high prevalence of nutritional iron deficiency have highlighted the need for reliable epidemiologic methods to assess iron status. The present report describes a method for estimating body iron based on the ratio of the serum transferrin receptor to serum ferritin. Analysis showed a single normal distribution of body iron stores in US men aged 20 to 65 years (mean ± 1 SD, 9.82 ± 2.82 mg/kg). A single normal distribution was also observed in pregnant Jamaican women (mean ± 1 SD, 0.09 ± 4.48 mg/kg). Distribution analysis in US women aged 20 to 45 years indicated 2 populations; 93% of women had body iron stores averaging 5.5 ± 3.35 mg/kg (mean ± 1 SD), whereas the remaining 7% of women had a mean tissue iron deficit of 3.87 ± 3.23 mg/kg. Calculations of body iron in trials of iron supplementation in Jamaica and iron fortification in Vietnam demonstrated that the method can be used to calculate absorption of the added iron. Quantitative estimates of body iron greatly enhance the evaluation of iron status and the sensitivity of iron intervention trials in populations in which inflammation is uncommon or has been excluded by laboratory screening. The method is useful clinically for monitoring iron status in those who are highly susceptible to iron deficiency. © 2003 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Muthayya, A. Eilander, C. Transler, T. 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F Hurrell, and N. Chaouki Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron. Am. J. Clinical Nutrition, September 1, 2006; 84(3): 580 - 586. [Abstract] [Full Text] [PDF] K. B Hadley, L. K Johnson, and J. R Hunt Iron absorption by healthy women is not associated with either serum or urinary prohepcidin Am. J. Clinical Nutrition, July 1, 2006; 84(1): 150 - 155. [Abstract] [Full Text] [PDF] R. Wegmuller, F. Camara, M. B. Zimmermann, P. Adou, and R. F. Hurrell Salt Dual-Fortified with Iodine and Micronized Ground Ferric Pyrophosphate Affects Iron Status but Not Hemoglobin in Children in Cote d'Ivoire J. Nutr., July 1, 2006; 136(7): 1814 - 1820. [Abstract] [Full Text] [PDF] D. W. Swinkels, M. C.H. Janssen, J. Bergmans, and J. J.M. Marx Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches Clin. Chem., June 1, 2006; 52(6): 950 - 968. 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Clinical Nutrition, December 1, 2005; 82(6): 1276 - 1282. [Abstract] [Full Text] [PDF] J. D. Haas, J. L. Beard, L. E. Murray-Kolb, A. M. del Mundo, A. Felix, and G. B. Gregorio Iron-Biofortified Rice Improves the Iron Stores of Nonanemic Filipino Women J. Nutr., December 1, 2005; 135(12): 2823 - 2830. [Abstract] [Full Text] [PDF] F. T Wieringa and M. A Dijkhuizen Validity of the dose-response tests for the determination of vitamin A status Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1138 - 1139. [Full Text] [PDF] L. L. Iannotti, K. O. O'Brien, S.-C. Chang, J. Mancini, M. Schulman-Nathanson, S. Liu, Z. L. Harris, and F. R. Witter Iron Deficiency Anemia and Depleted Body Iron Reserves Are Prevalent among Pregnant African-American Adolescents J. Nutr., November 1, 2005; 135(11): 2572 - 2577. [Abstract] [Full Text] [PDF] P. Van Thuy, J. Berger, Y. Nakanishi, N. C. Khan, S. Lynch, and P. 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Clinical Nutrition, July 1, 2005; 82(1): 98 - 102. [Abstract] [Full Text] [PDF] A. T. Chan, J. Ma, G. J. Tranah, E. L. Giovannucci, N. Rifai, D. J. Hunter, and C. S. Fuchs Hemochromatosis Gene Mutations, Body Iron Stores, Dietary Iron, and Risk of Colorectal Adenoma in Women J Natl Cancer Inst, June 15, 2005; 97(12): 917 - 926. [Abstract] [Full Text] [PDF] M. B Zimmermann, N. Chaouki, and R. F Hurrell Iron deficiency due to consumption of a habitual diet low in bioavailable iron: a longitudinal cohort study in Moroccan children Am. J. Clinical Nutrition, January 1, 2005; 81(1): 115 - 121. [Abstract] [Full Text] [PDF] M. B Zimmermann, R. Wegmueller, C. Zeder, N. Chaouki, R. Biebinger, R. F Hurrell, and E. Windhab Triple fortification of salt with microcapsules of iodine, iron, and vitamin A Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1283 - 1290. [Abstract] [Full Text] [PDF] J. G. Erhardt, J. E. Estes, C. M. Pfeiffer, H. K. Biesalski, and N. E. Craft Combined Measurement of Ferritin, Soluble Transferrin Receptor, Retinol Binding Protein, and C-Reactive Protein by an Inexpensive, Sensitive, and Simple Sandwich Enzyme-Linked Immunosorbent Assay Technique J. Nutr., November 1, 2004; 134(11): 3127 - 3132. [Abstract] [Full Text] [PDF] M. B Zimmermann, R. Wegmueller, C. Zeder, N. Chaouki, F. Rohner, M. Saissi, T. Torresani, and R. F Hurrell Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial Am. J. Clinical Nutrition, October 1, 2004; 80(4): 952 - 959. [Abstract] [Full Text] [PDF] C. Brugnara Iron Deficiency and Erythropoiesis: New Diagnostic Approaches Clin. Chem., October 1, 2003; 49(10): 1573 - 1578. [Abstract] [Full Text] [PDF] P. V. Thuy, J. Berger, L. Davidsson, N. C. Khan, N. T. Lam, J. D Cook, R. F Hurrell, and H. H. Khoi Regular consumption of NaFeEDTA-fortified fish sauce improves iron status and reduces the prevalence of anemia in anemic Vietnamese women Am. J. Clinical Nutrition, August 1, 2003; 78(2): 284 - 290. [Abstract] [Full Text] [PDF] E. Beutler, A. V. Hoffbrand, and J. D. Cook Iron Deficiency and Overload Hematology, January 1, 2003; 2003(1): 40 - 61. [Abstract] [Full Text] [PDF]

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