SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on March 20, 2003; DOI 10.1182/blood-2002-10-3170. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-10-3170v1 102/1/388    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by James, E. Articles by Simpson, E. Search for Related Content PubMed PubMed Citation Articles by James, E. Articles by Simpson, E. Related Collections Transplantation Immunotherapy Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 July 2003, Vol. 102, No. 1, pp. 388-393 TRANSPLANTATION Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans Edward James, Jian-Guo Chai, Hamlata Dewchand, Eugenio Macchiarulo, Francesco Dazzi, and Elizabeth Simpson From the Transplantation Biology Group, Medical Research Council (MRC) Clinical Sciences Centre, Department of Immunology, Faculty of Medicine, Imperial College of Science, Technology & Medicine, Hammersmith Hospital, London, United Kingdom. One of the factors that increases the risk of graft-versus-host disease following allogeneic stem cell transplantation is the use of multiparous females as donors. Since minor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leukemia responses, we tested the hypothesis that multiparity could prime minor H antigen—specific T cells. We examined the peripheral lymphoid populations of multiparous mice and humans for evidence of priming of CD8+ T-cytotoxic lymphocytes against peptide epitopes of the male-specific minor H antigen, HY. In contrast to naive females, multiparous females have measurable levels of circulating HY-specific tetramer-positive T lymphocytes, which can be readily expanded in vitro. These findings have implications for the in vitro generation of T-cell clones as reagents for immunotherapy for tumors following stem cell transplantation. (Blood. 2003; 102:388-393) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. S. Nielsen, L. Mortensen, U. Nygaard, O. Schnor, O. B. Christiansen, and A.-M. N. Andersen Brothers and Reduction of the Birth Weight of Later-born Siblings Am. J. Epidemiol., February 15, 2008; 167(4): 480 - 484. [Abstract] [Full Text] [PDF] C. M. Constantin, D. Masopust, T. Gourley, J. Grayson, O. L. Strickland, R. Ahmed, and E. A. Bonney Normal Establishment of Virus-Specific Memory CD8 T Cell Pool following Primary Infection during Pregnancy J. Immunol., October 1, 2007; 179(7): 4383 - 4389. [Abstract] [Full Text] [PDF] K. P. Piper, A. McLarnon, J. Arrazi, C. Horlock, J. Ainsworth, M. D. Kilby, W. L. Martin, and P. A. Moss Functional HY-Specific CD8+ T Cells Are Found in a High Proportion of Women Following Pregnancy with a Male Fetus Biol Reprod, January 1, 2007; 76(1): 96 - 101. [Abstract] [Full Text] [PDF] K.-i. Matsuoka, T. Ichinohe, D. Hashimoto, S. Asakura, M. Tanimoto, and T. Teshima Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+CD25+ T-cell-dependent mechanism Blood, January 1, 2006; 107(1): 404 - 409. [Abstract] [Full Text] [PDF] D. B. Miklos, H. T. Kim, K. H. Miller, L. Guo, E. Zorn, S. J. Lee, E. P. Hochberg, C. J. Wu, E. P. Alyea, C. Cutler, et al. Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission Blood, April 1, 2005; 105(7): 2973 - 2978. [Abstract] [Full Text] [PDF] B. Mommaas, J. A. Stegehuis-Kamp, A. G. van Halteren, M. Kester, J. Enczmann, P. Wernet, G. Kogler, T. Mutis, A. Brand, and E. Goulmy Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1 Blood, February 15, 2005; 105(4): 1823 - 1827. [Abstract] [Full Text] [PDF] J.-G. Chai, E. James, H. Dewchand, E. Simpson, and D. Scott Transplantation tolerance induced by intranasal administration of HY peptides Blood, May 15, 2004; 103(10): 3951 - 3959. [Abstract] [Full Text] [PDF] T. Hill and S. Joyce Another cause for incompatibility: gestational priming of women by tissue antigens of men Blood, March 1, 2004; 103(5): 1570 - 1571. [Full Text] [PDF] R. M. Verdijk, A. Kloosterman, J. Pool, M. van de Keur, A. M. I. H. Naipal, A. G. S. van Halteren, A. Brand, T. Mutis, and E. Goulmy Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy Blood, March 1, 2004; 103(5): 1961 - 1964. [Abstract] [Full Text] [PDF] D. B. Miklos, H. T. Kim, E. Zorn, E. P. Hochberg, L. Guo, A. Mattes-Ritz, S. Viatte, R. J. Soiffer, J. H. Antin, and J. Ritz Antibody response to DBY minor histocompatibility antigen is induced after allogeneic stem cell transplantation and in healthy female donors Blood, January 1, 2004; 103(1): 353 - 359. [Abstract] [Full Text] [PDF]

	Blood Online is supported in part by Genentech BioOncology and Biogen Idec
	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020