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Blood, 15 November 2003, Vol. 102, No. 10, pp. 3693-3701. Prepublished online as a Blood First Edition Paper on July 24, 2003; DOI 10.1182/blood-2003-04-1016. This Article Full Text Full Text (PDF) Supplemental Data All Versions of this Article: 2003-04-1016v1 102/10/3693    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brandes, M. Articles by Moser, B. Search for Related Content PubMed PubMed Citation Articles by Brandes, M. Articles by Moser, B. Related Collections Immunobiology Cell Adhesion and Motility Chemokines, Cytokines, and Interleukins Gene Therapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Flexible migration program regulates T-cell involvement in humoral immunity Marlène Brandes, Katharina Willimann, Alois B. Lang, Ki-Hoan Nam, Chenggang Jin, Michael B. Brenner, Craig T. Morita, and Bernhard Moser From the Theodor-Kocher Institute, University of Bern, Switzerland; Berna Biotech, Bern, Switzerland; Division of Rheumatology, Department of Internal Medicine and the Interdisciplinary Group in Immunology, University of Iowa College of Medicine, Iowa City; and Brigham and Women's Hospital and Harvard Medical School, Boston, MA. T cells are inadequately defined both in terms of their migration potential and contribution to antimicrobial immunity. Here, we have examined the migration profile of human blood T cells and related cell lines and correlated these findings with their distribution in secondary lymphoid tissues and their function in B-cell cocultures. We find that resting T cells are characterized by an inflammatory migration program similar to cells of the innate immune system. However, T-cell receptor (TCR) triggering resulted in the rapid but transient induction of a lymph node (LN)-homing program, as evidenced by functional CCR7 expression and concomitant reduction in expression and function of CCR5 and, to a lesser degree, CCR2. Moreover, the LN-homing program was reflected by the presence of T cells in gastrointestinal lymphoid tissues, notably in clusters within germinal centers of B-cell follicles. In line with these findings, VV-TCR triggering resulted in prominent expression of essential B-cell costimulatory molecules, including CD40L, OX40, CD70, and ICOS. Furthermore, T cells were shown to provide potent B-cell help during in vitro antibody production. Collectively, our findings agree with a role for T cells in humoral immunity during the early phase of antimicrobial responses. (Blood. 2003; 102:3693-3701) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. Pitard, D. Roumanes, X. Lafarge, L. Couzi, I. Garrigue, M.-E. Lafon, P. Merville, J.-F. Moreau, and J. Dechanet-Merville Long-term expansion of effector/memory V{delta}2- {gamma}{delta} T cells is a specific blood signature of CMV infection Blood, August 15, 2008; 112(4): 1317 - 1324. [Abstract] [Full Text] [PDF] I. Van Rhijn, V. P. M. G. Rutten, B. Charleston, M. Smits, W. van Eden, and A. P. Koets Massive, sustained {gamma}{delta} T cell migration from the bovine skin in vivo J. Leukoc. Biol., April 1, 2007; 81(4): 968 - 973. [Abstract] [Full Text] [PDF] D. Vermijlen, P. Ellis, C. Langford, A. 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