|
|
Blood, 15 November 2003, Vol. 102, No. 10, pp. 3775-3785.
Prepublished online as a Blood First Edition Paper on August 7, 2003; DOI 10.1182/blood-2003-05-1683.
 Previous Article | Table of Contents | Next Article 
NEOPLASIA
Molecular histogenesis of posttransplantation lymphoproliferative disorders
Daniela Capello,
Michaela Cerri,
Giuliana Muti,
Eva Berra,
Pierluigi Oreste,
Clara Deambrogi,
Davide Rossi,
Giampietro Dotti,
Annarita Conconi,
Mario Viganò,
Umberto Magrini,
Giovanbattista Ippoliti,
Enrica Morra,
Annunziata Gloghini,
Alessandro Rambaldi,
Marco Paulli,
Antonino Carbone, and
Gianluca Gaidano
From the Hematology Unit, Department of Medical Sciences and Interdisciplinary Research Center on Autoimmune Diseases (IRCAD), Amedeo Avogadro University of Eastern Piedmont, Novara, Italy; the Divisions of Hematology and Pathology, Ospedale Niguarda Ca' Granda, Milan, Italy; the Division of Hematology, Ospedali Riuniti, Bergamo, Italy; the Cardiac Surgery Unit and Department of Pathology, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo/University of Pavia, Pavia, Italy; the Division of Internal Medicine, Ospedale Civile di Voghera/A. O. Pavia, Voghera, Italy; and the Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy.
Posttransplantation lymphoproliferative disorders (PTLDs) represent a serious complication of solid organ transplantation. This study assessed the molecular histogenesis of 52 B-cell monoclonal PTLDs, including 12 polymorphic PTLDs (P-PTLDs), 36 diffuse large B-cell lymphomas (DLBCLs), and 4 Burkitt/Burkitt-like lymphomas (BL/BLLs). Somatic hypermutation (SHM) of immunoglobulin variable (IgV) genes documented that most monoclonal B-cell PTLDs (75% P-PTLDs, 91.3% DLBCLs, 100% BL/BLLs) derive from germinal center (GC)-experienced B cells. B-cell lymphoma 6 (BCL6) mutations occurred in 25% P-PTLDs, 60.6% DLBCLs, and 75.0% BL/BLLs. A first histogenetic category of PTLDs (31.2% DLBCLs) express the BCL6+/multiple myeloma oncogene-1 protein (MUM1-/+)/CD138- profile and mimic B cells experiencing the GC reaction, as also suggested by ongoing SHM in a fraction of these cases. A second subset of PTLDs (66.7% P-PTLDs and 31.2% DLBCLs) display the BCL6-/MUM1+/CD138- phenotype and mimic B cells that have concluded the GC reaction. A third histogenetic category of PTLDs (25.0% P-PTLDs and 31.2% DLBCLs) shows the BCL6-/MUM1+/CD138+ profile, consistent with preterminally differentiated post-GC B cells. Crippling mutations of IgV heavy chain (IgVH) and/or IgV light chain (IgVL) genes, leading to sterile rearrangements and normally preventing cell survival, occur in 4 DLBCLs and 1 BL/BLL that may have been rescued from apoptosis through expression of Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1). Overall, the histogenetic diversity of monoclonal B-cell PTLDs may help define biologically homogeneous categories of the disease. (Blood. 2003;102: 3775-3785)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Paulli, L. Arcaini, M. Lucioni, E. Boveri, D. Capello, F. Passamonti, M. Merli, S. Rattotti, D. Rossi, R. Riboni, et al.
Subcutaneous 'lipoma-like' B-cell lymphoma associated with HCV infection: a new presentation of primary extranodal marginal zone B-cell lymphoma of MALT
Ann. Onc.,
October 25, 2009;
(2009)
mdp454v1.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Del Giudice, S. Chiaretti, S. Tavolaro, M. S. De Propris, R. Maggio, F. Mancini, N. Peragine, S. Santangelo, M. Marinelli, F. R. Mauro, et al.
Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases
Blood,
July 16, 2009;
114(3):
638 - 646.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Rossi, V. Spina, M. Cerri, S. Rasi, C. Deambrogi, L. De Paoli, L. Laurenti, R. Maffei, F. Forconi, F. Bertoni, et al.
Stereotyped B-Cell Receptor Is an Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Clin. Cancer Res.,
July 1, 2009;
15(13):
4415 - 4422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. T. Tan, K. Seo, R. A. Warnke, and D. A. Arber
The Frequency of Immunoglobulin Heavy Chain Gene and T-Cell Receptor {gamma}-Chain Gene Rearrangements and Epstein-Barr Virus in ALK+ and ALK- Anaplastic Large Cell Lymphoma and Other Peripheral T-Cell Lymphomas
J. Mol. Diagn.,
November 1, 2008;
10(6):
502 - 512.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Capello, M. Martini, A. Gloghini, M. Cerri, S. Rasi, C. Deambrogi, D. Rossi, M. Spina, U. Tirelli, L. M. Larocca, et al.
Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis
Haematologica,
August 1, 2008;
93(8):
1178 - 1185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H-J Delecluse, R Feederle, B O'Sullivan, and P Taniere
Epstein Barr virus-associated tumours: an update for the attention of the working pathologist
J. Clin. Pathol.,
December 1, 2007;
60(12):
1358 - 1364.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. N. Naresh
MUM1 expression dichotomizes follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes
Haematologica,
February 1, 2007;
92(2):
267 - 268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. McCrae, D. C. Matthews, and M. Linenberger
Consultative hematology
ASH Self-Assessment Program,
January 1, 2007;
2007(1):
466 - 505.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tobollik, L. Meyer, M. Buettner, S. Klemmer, B. Kempkes, E. Kremmer, G. Niedobitek, and B. Jungnickel
Epstein-Barr virus nuclear antigen 2 inhibits AID expression during EBV-driven B-cell growth
Blood,
December 1, 2006;
108(12):
3859 - 3864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. LaCasce
Post-transplant lymphoproliferative disorders.
Oncologist,
June 1, 2006;
11(6):
674 - 680.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Chaganti, A. I. Bell, N. B. Pastor, A. E. Milner, M. Drayson, J. Gordon, and A. B. Rickinson
Epstein-Barr virus infection in vitro can rescue germinal center B cells with inactivated immunoglobulin genes
Blood,
December 15, 2005;
106(13):
4249 - 4252.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Bechtel, J. Kurth, C. Unkel, and R. Kuppers
Transformation of BCR-deficient germinal-center B cells by EBV supports a major role of the virus in the pathogenesis of Hodgkin and posttransplantation lymphomas
Blood,
December 15, 2005;
106(13):
4345 - 4350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. M. Ghobrial, T. M. Habermann, M. J. Maurer, S. M. Geyer, K. M. Ristow, T. S. Larson, R. C. Walker, S. M. Ansell, W. R. Macon, G. G. Gores, et al.
Prognostic Analysis for Survival in Adult Solid Organ Transplant Recipients With Post-Transplantation Lymphoproliferative Disorders
J. Clin. Oncol.,
October 20, 2005;
23(30):
7574 - 7582.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Carbone, A. Gloghini, E. Vaccher, M. Cerri, G. Gaidano, R. Dalla-Favera, and U. Tirelli
Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus Type 8-Positive Solid Lymphomas: A Tissue-Based Variant of Primary Effusion Lymphoma
J. Mol. Diagn.,
February 1, 2005;
7(1):
17 - 27.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
