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Blood, 15 November 2003, Vol. 102, No. 10, pp. 3797-3799. Prepublished online as a Blood First Edition Paper on July 3, 2003; DOI 10.1182/blood-2003-03-0899. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-03-0899v1 102/10/3797    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gniadecki, R. Articles by Wulf, H. C. Search for Related Content PubMed PubMed Citation Articles by Gniadecki, R. Articles by Wulf, H. C. Related Collections Immunobiology Neoplasia Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Bone marrow precursor of extranodal T-cell lymphoma Robert Gniadecki, Ansgar Lukowsky, Kristian Rossen, Hans O. Madsen, Kristian Thomsen, and Hans Christian Wulf From the Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark; Department of Dermatology, Humboldt University Charité, Berlin, Germany; Department of Pathology, University of Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark; and Department of Clinical Immunology, The National University Hospital (Rigshospitalet), Copenhagen, Denmark. The development of extranodal lymphomas is thought to be initiated by the transformation event in peripheral organs. Lymphomatoid papulosis (LyP) is a low-grade cutaneous lymphoma and may progress into the cutaneous anaplastic lymphoma. We identified 2 patients who 3 and 4 years before the development of LyP were treated for an unrelated malignancy (Burkitt lymphoma and small-cell B-cell lymphoma). We analyzed the T-cell receptor (TCR) gene rearrangement pattern in their skin, blood, and bone marrow, including the archival bone marrow sampled years before the development of clinically evident LyP. In all samples we detected the unique monoclonal TCR rearrangements. This observation suggests that the initial malignant transformation in LyP occurred in bone marrow and not, as could be supposed, in the skin. (Blood. 2003;102:3797-3799) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Guitart and C. Magro Cutaneous T-Cell Lymphoid Dyscrasia: A Unifying Term for Idiopathic Chronic Dermatoses With Persistent T-Cell Clones Arch Dermatol, July 1, 2007; 143(7): 921 - 932. [Abstract] [Full Text] [PDF] R. Gniadecki Do Neoplastic Stem Cells Underlie the Pathogenesis of Cutaneous Lymphomas?--Reply Arch Dermatol, May 1, 2005; 141(5): 642 - 643. [Full Text] [PDF] R. Gniadecki and A. Lukowsky Monoclonal T-Cell Dyscrasia of Undetermined Significance Associated With Recalcitrant Erythroderma Arch Dermatol, March 1, 2005; 141(3): 361 - 367. [Abstract] [Full Text] [PDF] R. Gniadecki Neoplastic Stem Cells in Cutaneous Lymphomas: Evidence and Clinical Implications Arch Dermatol, September 1, 2004; 140(9): 1156 - 1160. [Full Text] [PDF] J. R. Brown and A. T. Skarin Clinical Mimics of Lymphoma Oncologist, July 1, 2004; 9(4): 406 - 416. [Abstract] [Full Text] [PDF]

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