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Blood, 1 December 2003, Vol. 102, No. 12, pp. 3900-3905.
Prepublished online as a Blood First Edition Paper on August 7, 2003; DOI 10.1182/blood-2003-02-0641.
 Previous Article | Table of Contents | Next Article 
CHEMOKINES
Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis
Lei Yao,
Ombretta Salvucci,
Adela R. Cardones,
Sam T. Hwang,
Yoshiyasu Aoki,
Maria De La Luz Sierra,
Agatha Sajewicz,
Stefania Pittaluga,
Robert Yarchoan, and
Giovanna Tosato
From the Experimental Transplantation and Immunology Branch, the Dermatology Branch, the Laboratory of Pathology, and the HIV and AIDS Malignancy Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD.
Kaposi sarcoma (KS), the most common neoplasm in patients with AIDS, typically presents with multiple skin lesions characterized by "spindle cells," the vast majority of which are infected with KSHV (Kaposi sarcoma herpes virus, also named HHV-8). In patients with AIDS, the presence of cell-associated KSHV DNA in blood is predictive of subsequent KS development, but the mechanisms by which circulating KSHV-infected cells contribute to AIDS-KS pathogenesis are unclear. Here, we show that the chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed by skin capillary endothelium and displayed on the endothelial cell surface in association with heparan sulfate, can trigger specific arrest of KSHV-infected cells under physiologic shear flow conditions. Moreover, in the presence of soluble SDF-1 gradients, SDF-1 expressed on the endothelial barrier can promote transendothelial migration of KSHV-infected cells. By triggering specific adhesion of circulating KSHV-infected cells and favoring their entry into the extravascular cutaneous space, endothelial cell–associated SDF-1 in cutaneous capillaries may dictate the preferential occurrence of KS in the skin.
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