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Blood, 1 December 2003, Vol. 102, No. 12, pp. 3900-3905. Prepublished online as a Blood First Edition Paper on August 7, 2003; DOI 10.1182/blood-2003-02-0641. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-02-0641v1 102/12/3900    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yao, L. Articles by Tosato, G. Search for Related Content PubMed PubMed Citation Articles by Yao, L. Articles by Tosato, G. Related Collections Hemostasis, Thrombosis, and Vascular Biology Neoplasia Cell Adhesion and Motility Signal Transduction Gene Expression Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CHEMOKINES Selective expression of stromal-derived factor-1 in the capillary vascular endothelium plays a role in Kaposi sarcoma pathogenesis Lei Yao, Ombretta Salvucci, Adela R. Cardones, Sam T. Hwang, Yoshiyasu Aoki, Maria De La Luz Sierra, Agatha Sajewicz, Stefania Pittaluga, Robert Yarchoan, and Giovanna Tosato From the Experimental Transplantation and Immunology Branch, the Dermatology Branch, the Laboratory of Pathology, and the HIV and AIDS Malignancy Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD. Kaposi sarcoma (KS), the most common neoplasm in patients with AIDS, typically presents with multiple skin lesions characterized by "spindle cells," the vast majority of which are infected with KSHV (Kaposi sarcoma herpes virus, also named HHV-8). In patients with AIDS, the presence of cell-associated KSHV DNA in blood is predictive of subsequent KS development, but the mechanisms by which circulating KSHV-infected cells contribute to AIDS-KS pathogenesis are unclear. Here, we show that the chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed by skin capillary endothelium and displayed on the endothelial cell surface in association with heparan sulfate, can trigger specific arrest of KSHV-infected cells under physiologic shear flow conditions. Moreover, in the presence of soluble SDF-1 gradients, SDF-1 expressed on the endothelial barrier can promote transendothelial migration of KSHV-infected cells. By triggering specific adhesion of circulating KSHV-infected cells and favoring their entry into the extravascular cutaneous space, endothelial cell–associated SDF-1 in cutaneous capillaries may dictate the preferential occurrence of KS in the skin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Salvucci, D. Maric, M. Economopoulou, S. Sakakibara, S. Merlin, A. Follenzi, and G. Tosato EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures Blood, August 20, 2009; 114(8): 1707 - 1716. [Abstract] [Full Text] [PDF] S. Sadagopan, N. Sharma-Walia, M. V. Veettil, V. Bottero, R. Levine, R. J. Vart, and B. Chandran Kaposi's Sarcoma-Associated Herpesvirus Upregulates Angiogenin during Infection of Human Dermal Microvascular Endothelial Cells, Which Induces 45S rRNA Synthesis, Antiapoptosis, Cell Proliferation, Migration, and Angiogenesis J. Virol., April 1, 2009; 83(7): 3342 - 3364. [Abstract] [Full Text] [PDF] P. Gasperini, S. Sakakibara, and G. Tosato Contribution of viral and cellular cytokines to Kaposi's sarcoma-associated herpesvirus pathogenesis J. Leukoc. Biol., October 1, 2008; 84(4): 994 - 1000. [Abstract] [Full Text] [PDF] C. K. Williams, M. Segarra, M. De La Luz Sierra, R. C.A. Sainson, G. Tosato, and A. L. Harris Regulation of CXCR4 by the Notch Ligand Delta-like 4 in Endothelial Cells Cancer Res., March 15, 2008; 68(6): 1889 - 1895. [Abstract] [Full Text] [PDF] E. Spiekerkoetter, C. M. Alvira, Y.-M. Kim, A. Bruneau, K. L. Pricola, L. Wang, N. Ambartsumian, and M. Rabinovitch Reactivation of {gamma}HV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L276 - L289. [Abstract] [Full Text] [PDF] T. Yano, Z. Liu, J. Donovan, M. K. Thomas, and J. F. Habener Stromal Cell Derived Factor-1 (SDF-1)/CXCL12 Attenuates Diabetes in Mice and Promotes Pancreatic {beta}-Cell Survival by Activation of the Prosurvival Kinase Akt Diabetes, December 1, 2007; 56(12): 2946 - 2957. [Abstract] [Full Text] [PDF] T. H. Schreiber, V. Shinder, D. W. Cain, R. Alon, and R. Sackstein Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm Blood, February 15, 2007; 109(4): 1381 - 1386. [Abstract] [Full Text] [PDF] O. Salvucci, M. de la Luz Sierra, J. A. Martina, P. J. McCormick, and G. Tosato EphB2 and EphB4 receptors forward signaling promotes SDF-1-induced endothelial cell chemotaxis and branching remodeling Blood, November 1, 2006; 108(9): 2914 - 2922. [Abstract] [Full Text] [PDF] L. Wang, D. P. Dittmer, C. C. Tomlinson, F. D. Fakhari, and B. Damania Immortalization of Primary Endothelial Cells by the K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus. Cancer Res., April 1, 2006; 66(7): 3658 - 3666. [Abstract] [Full Text] [PDF] D. A. Davis, K. E. Singer, M. De La Luz Sierra, M. Narazaki, F. Yang, H. M. Fales, R. Yarchoan, and G. Tosato Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1{alpha} in the circulation Blood, June 15, 2005; 105(12): 4561 - 4568. [Abstract] [Full Text] [PDF] M. C. Cheung, L. Pantanowitz, and B. J. Dezube AIDS-Related Malignancies: Emerging Challenges in the Era of Highly Active Antiretroviral Therapy Oncologist, June 1, 2005; 10(6): 412 - 426. [Abstract] [Full Text] [PDF] R. Sadir, A. Imberty, F. Baleux, and H. Lortat-Jacob Heparan Sulfate/Heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 against Proteolysis Induced by CD26/Dipeptidyl Peptidase IV J. Biol. Chem., October 15, 2004; 279(42): 43854 - 43860. [Abstract] [Full Text] [PDF] Y. Aoki and G. Tosato HIV-1 Tat enhances Kaposi sarcoma-associated herpesvirus (KSHV) infectivity Blood, August 1, 2004; 104(3): 810 - 814. [Abstract] [Full Text] [PDF] O. Salvucci, M. Basik, L. Yao, R. Bianchi, and G. Tosato Evidence for the involvement of SDF-1 and CXCR4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by TNF-{alpha} and IFN-{gamma} J. Leukoc. Biol., July 1, 2004; 76(1): 217 - 226. [Abstract] [Full Text] [PDF] M. De La Luz Sierra, F. Yang, M. Narazaki, O. Salvucci, D. Davis, R. Yarchoan, H. H. Zhang, H. Fales, and G. Tosato Differential processing of stromal-derived factor-1{alpha} and stromal-derived factor-1{beta} explains functional diversity Blood, April 1, 2004; 103(7): 2452 - 2459. [Abstract] [Full Text] [PDF]

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