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Blood, 1 December 2003, Vol. 102, No. 12, pp. 3912-3918. Prepublished online as a Blood First Edition Paper on August 14, 2003; DOI 10.1182/blood-2003-06-1856. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-06-1856v1 102/12/3912    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Deeg, H. J. Articles by Appelbaum, F. R. Search for Related Content PubMed PubMed Citation Articles by Deeg, H. J. Articles by Appelbaum, F. R. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Allogeneic hematopoietic stem cell transplantation for myelofibrosis H. Joachim Deeg, Theodore A. Gooley, Mary E. D. Flowers, George E. Sale, John T. Slattery, Claudio Anasetti, Thomas R. Chauncey, Kristine Doney, George E. Georges, Hans-Peter Kiem, Paul J. Martin, Effie W. Petersdorf, Jerald Radich, Jean E. Sanders, Brenda M. Sandmaier, E. Houston Warren, Robert P. Witherspoon, Rainer Storb, and Frederick R. Appelbaum From the Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA; and the Seattle VA Medical Center, Seattle, WA. Fifty-six patients, 10 to 66 years of age, with idiopathic myelofibrosis (IMF) or end-stage polycythemia vera or essential thrombocythemia received allogeneic hematopoietic cell transplants from related (n = 36) or unrelated (n = 20) donors. Forty-four patients were prepared with busulfan plus cyclophosphamide and 12 with total body irradiation plus chemotherapy. The source of stem cells was marrow in 33 and peripheral blood in 23 patients. All but 3 patients achieved engraftment. While 50 patients showed complete donor chimerism, 3 patients were found to be mixed chimeras at 26, 48, and 86 months after transplantation, respectively. Two patients died from relapse/progressive disease, and 18 died from other causes. There are 36 patients surviving at 0.5 to 11.6 (median, 2.8) years, for a 3-year Kaplan-Meier estimate of 58% (CI, 43%-73%). Dupriez score, cytogenetic abnormalities, and degree of marrow fibrosis were the most significant risk factors for posttransplantation mortality. Patients conditioned with a regimen of busulfan targeted to plasma levels of 800 to 900 ng/mL plus cyclophosphamide had a higher probability of survival (76% [CI, 62%-91%]) than other patients. Results with unrelated donors were comparable with those with HLA-identical sibling transplants. Thus, allogeneic hematopoietic cell transplantation offers long-term relapse-free survival for patients with myelofibrosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Passamonti, E. Rumi, M. Caramella, C. Elena, L. Arcaini, E. Boveri, C. Del Curto, D. Pietra, L. Vanelli, P. Bernasconi, et al. A dynamic prognostic model to predict survival in post-polycythemia vera myelofibrosis Blood, April 1, 2008; 111(7): 3383 - 3387. [Abstract] [Full Text] [PDF] A. Tefferi Primary myelofibrosis and its paraneoplastic stromal effects Haematologica, May 1, 2007; 92(5): 577 - 579. [Full Text] [PDF] N. Kroger, A. Badbaran, E. 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Verstovsek Advances in the Therapy of Chronic Idiopathic Myelofibrosis Oncologist, September 1, 2006; 11(8): 929 - 943. [Abstract] [Full Text] [PDF] A. Tefferi, G. Barosi, R. A. Mesa, F. Cervantes, H. J. Deeg, J. T. Reilly, S. Verstovsek, B. Dupriez, R. T. Silver, O. Odenike, et al. International Working Group (IWG) consensus criteria for treatment response in myelofibrosis with myeloid metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT) Blood, September 1, 2006; 108(5): 1497 - 1503. [Abstract] [Full Text] [PDF] A. Tefferi, J. Cortes, S. Verstovsek, R. A. Mesa, D. Thomas, T. L. Lasho, W. J. Hogan, M. R. Litzow, J. B. Allred, D. Jones, et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia Blood, August 15, 2006; 108(4): 1158 - 1164. [Abstract] [Full Text] [PDF] R. L. Levine and G. Wernig Role of JAK-STAT Signaling in the Pathogenesis of Myeloproliferative Disorders Hematology, January 1, 2006; 2006(1): 233 - 239. [Abstract] [Full Text] [PDF] A. 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Rana, R. Lorenzini, et al. A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-{beta}1 in the development of myelofibrosis Blood, May 1, 2005; 105(9): 3493 - 3501. [Abstract] [Full Text] [PDF] R. A. Mesa, C.-Y. Li, R. P. Ketterling, G. S. Schroeder, R. A. Knudson, and A. Tefferi Leukemic transformation in myelofibrosis with myeloid metaplasia: a single-institution experience with 91 cases Blood, February 1, 2005; 105(3): 973 - 977. [Abstract] [Full Text] [PDF] H. Baurmann, I. Burlakowa, J. Kaltenhaeuser, D. Judith, M. Heshmat, F. Collenbusch, R. Conradi, M. Schleuning, and R. Schwerdtfeger Allogeneic Hematopoietic Stem Cell Transplantation in Myelofibrosis with Myeloid Metaplasia (MMM) - Transplantation Should Be Performed before Transfusion Dependence Occurs. Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 1513 - 1513. [Abstract] S. O'Brien, A. Tefferi, and P. 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