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 Blood, 1 December 2003, Vol. 102, No. 12, pp. 3912-3918.
Prepublished online as a Blood First Edition Paper on August 14, 2003; DOI 10.1182/blood-2003-06-1856.

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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS

Allogeneic hematopoietic stem cell transplantation for myelofibrosis

H. Joachim Deeg, Theodore A. Gooley, Mary E. D. Flowers, George E. Sale, John T. Slattery, Claudio Anasetti, Thomas R. Chauncey, Kristine Doney, George E. Georges, Hans-Peter Kiem, Paul J. Martin, Effie W. Petersdorf, Jerald Radich, Jean E. Sanders, Brenda M. Sandmaier, E. Houston Warren, Robert P. Witherspoon, Rainer Storb, and Frederick R. Appelbaum

From the Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA; and the Seattle VA Medical Center, Seattle, WA.

Fifty-six patients, 10 to 66 years of age, with idiopathic myelofibrosis (IMF) or end-stage polycythemia vera or essential thrombocythemia received allogeneic hematopoietic cell transplants from related (n = 36) or unrelated (n = 20) donors. Forty-four patients were prepared with busulfan plus cyclophosphamide and 12 with total body irradiation plus chemotherapy. The source of stem cells was marrow in 33 and peripheral blood in 23 patients. All but 3 patients achieved engraftment. While 50 patients showed complete donor chimerism, 3 patients were found to be mixed chimeras at 26, 48, and 86 months after transplantation, respectively. Two patients died from relapse/progressive disease, and 18 died from other causes. There are 36 patients surviving at 0.5 to 11.6 (median, 2.8) years, for a 3-year Kaplan-Meier estimate of 58% (CI, 43%-73%). Dupriez score, cytogenetic abnormalities, and degree of marrow fibrosis were the most significant risk factors for posttransplantation mortality. Patients conditioned with a regimen of busulfan targeted to plasma levels of 800 to 900 ng/mL plus cyclophosphamide had a higher probability of survival (76% [CI, 62%-91%]) than other patients. Results with unrelated donors were comparable with those with HLA-identical sibling transplants. Thus, allogeneic hematopoietic cell transplantation offers long-term relapse-free survival for patients with myelofibrosis.


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