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Blood, 1 December 2003, Vol. 102, No. 12, pp. 4107-4114. Prepublished online as a Blood First Edition Paper on July 31, 2003; DOI 10.1182/blood-2003-04-1320. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-04-1320v1 102/12/4107    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cosmi, L. Articles by Annunziato, F. Search for Related Content PubMed PubMed Citation Articles by Cosmi, L. Articles by Annunziato, F. Related Collections Immunobiology Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes Lorenzo Cosmi, Francesco Liotta, Elena Lazzeri, Michela Francalanci, Roberta Angeli, Benedetta Mazzinghi, Veronica Santarlasci, Roberto Manetti, Vittorio Vanini, Paola Romagnani, Enrico Maggi, Sergio Romagnani, and Francesco Annunziato From the Department of Internal Medicine and Department of Pathophysiology, University of Florence, Florence, Italy; and Apuanic Pediatric Hospital, Massa Carrara, Italy CD8+CD25+ cells, which expressed high levels of Foxp3, glucocorticoid-induced tumor necrosis factor receptor (GITR), CCR8, tumor necrosis factor receptor 2 (TNFR2), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) mRNAs, were identified in the fibrous septa and medullary areas of human thymus. Activated CD8+CD25+ thymocytes did not produce cytokines, but most of them expressed surface CTLA-4 and transforming growth factor 1 (TGF-1). Like CD4+CD25+, CD8+CD25+ thymocytes suppressed the proliferation of autologous CD25-T cells via a contact-dependent mechanism. The suppressive activity of CD8+CD25+ thymocytes was abrogated by a mixture of anti-CTLA-4 and anti-TGF-1 antibodies and it was mediated by their ability to inhibit the expression of the interleukin 2 receptor chain on target T cells. These results demonstrate the existence of a subset of human CD8+CD25+ thymocytes sharing phenotype, functional features, and mechanism of action with CD4+CD25+ T regulatory cells. (Blood. 2003;102:4107-4114) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. Badoual, S. Hans, W. H. Fridman, D. Brasnu, S. Erdman, and E. Tartour Revisiting the Prognostic Value of Regulatory T Cells in Patients With Cancer J. 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