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Blood, 1 December 2003, Vol. 102, No. 12, pp. 4143-4145.
Prepublished online as a Blood First Edition Paper on July 31, 2003; DOI 10.1182/blood-2003-03-0779.
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IMMUNOBIOLOGY
Brief report
Circadian clock genes oscillate in human peripheral blood mononuclear cells
Diane B. Boivin,
Francine O. James,
Aibin Wu,
Park F. Cho-Park,
Huabao Xiong, and
Zhong S. Sun
From the Center for Study and Treatment of Circadian Rhythms, Douglas Hospital Research Center, Department of Psychiatry, McGill University, Montreal, QC, Canada; the Department of Pediatrics, Critical Care Division, Weill Medical College, Cornell University, New York, NY; and the Immunobiology Center, Mount Sinai School of Medicine, New York, NY.
In mammals, it is well documented that observable circadian rhythms are controlled by a central oscillator that is organized in transcriptional and translational feedback loops involving several clock genes. Although recent studies have demonstrated that clock genes oscillate in many peripheral tissues, their characteristics in the human immune system remain unknown. The present study investigates whether circadian clock genes function in human peripheral blood mononuclear cells. On the basis of studies derived from 3 human subjects under controlled conditions, circadian clock genes hPer1, hPer2, hPer3, and hDec1 are expressed in a circadian manner in human peripheral blood mononuclear cells (PBMCs), with the peak level occurring during the habitual time of activity. The demonstration of functional circadian machinery in human PBMCs suggests that peripheral blood cells may be useful for the investigation of human circadian rhythms and their associated disorders. (Blood. 2003;102:4143-4145)
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