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Blood, 15 December 2003, Vol. 102, No. 13, pp. 4306-4311. Prepublished online as a Blood First Edition Paper on August 28, 2003; DOI 10.1182/blood-2002-10-3317. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-10-3317v1 102/13/4306    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Webert, K. E. Articles by Kelton, J. G. Search for Related Content PubMed PubMed Citation Articles by Webert, K. E. Articles by Kelton, J. G. Related Collections Hemostasis, Thrombosis, and Vascular Biology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura Kathryn E. Webert, Richa Mittal, Christopher Sigouin, Nancy M. Heddle, and John G. Kelton From the Department of Medicine, McMaster University, Hamilton, Ontario, ON, Canada. Numerous studies have examined the outcomes of infants born to mothers with idiopathic thrombocytopenic purpura (ITP). Fewer studies have discussed the morbidity of obstetric patients with ITP. We describe a retrospective study of 92 women with ITP during 119 pregnancies over an 11-year period. Most women had thrombocytopenia during pregnancy. At delivery, women in 98 pregnancies (89%) had platelet counts lower than 150 x 109/L; most had mild to moderate thrombocytopenia. For many, the pregnancy was uneventful; however, women had moderate to severe bleeding in 25 pregnancies (21.5%). Women in 37 pregnancies (31.1%) required treatment to increase platelet counts. During delivery, 44 women (37.3%) received epidural analgesia without complications, with most having a platelet count between 50 and 149 x 109/L. Most deliveries (82.4%) were vaginal. Bleeding was uncommon at delivery. Infant platelet counts at birth ranged from 12 to 436 x 109/L; 25.2% of infants had platelet counts lower than 150 x 109/L, and 9% had platelet counts lower than 50 x 109/L. Eighteen infants (14.6%) required treatment for hemostatic impairment. Two fetal deaths occurred. One was caused by hemorrhage. ITP in pregnancy carries a low risk, but mothers and infants may require therapy to raise their platelet counts. (Blood. 2003;102:4306-4311) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Smolinsky, M. P Carson, E. R Guzman, A. Ranzini, J. Toscano, and A. Bukhari Aplastic anaemia in pregnancy with severe thrombocytopenia refractory to platelet transfusion: a case and management plan Obstet Med, March 1, 2009; 2(1): 26 - 29. [Abstract] [Full Text] [PDF] D. B. Cines and J. B. Bussel How I treat idiopathic thrombocytopenic purpura (ITP) Blood, October 1, 2005; 106(7): 2244 - 2251. [Full Text] [PDF]

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