SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on April 10, 2003; DOI 10.1182/blood-2003-03-0720. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-03-0720v1 102/3/1138    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Frassoni, F. Articles by Locatelli, F. Search for Related Content PubMed PubMed Citation Articles by Frassoni, F. Articles by Locatelli, F. Related Collections Hematopoiesis and Stem Cells Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2003, Vol. 102, No. 3, pp. 1138-1141 TRANSPLANTATION Brief report Cord blood transplantation provides better reconstitution of hematopoietic reservoir compared with bone marrow transplantation Francesco Frassoni, Marina Podestà, Rita Maccario, Giovanna Giorgiani, Gabriele Rossi, Marco Zecca, Andrea Bacigalupo, Giovanna Piaggio, and Franco Locatelli From the Centro Cellule Staminali e Terapia Cellulare, Dipartimento Emato-Oncologia, Ospedale San Martino, Genova, Italy; and Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, Pavia, Italy Delayed hematopoietic recovery is the main factor precluding a wider use of cord blood (CB) transplants. We hypothesized that this delayed engraftment might not be related to an insufficient number of stem cells in the graft, but to an intrinsic difficulty of these cells to undergo differentiation. To test our hypothesis, 2 groups of children were compared; 12 received a CB transplant and 12 an adult bone marrow (BM) transplant. We studied neutrophil and platelet recovery and, at a median time of approximately 1 year after transplantation, the frequency of colony-forming cells (CFCs) and long-term culture initiating cells (LTC-ICs) in the BM of the 2 groups. Recipients of BM transplants received 1-log more cells and had significantly faster neutrophil and platelet recovery. Conversely, the frequency of committed and early progenitors was significantly higher in the BM of children given CB cells compared with BM transplant recipients (median count of CFC/2 x 104 BM mononuclear cells, 20 versus 11, P = .007; median count of LTC-IC/106 BM mononuclear cells, 8.2 versus 0.2 P = .001). CB, but not adult BM stem cells, can better restore the host hematopoietic progenitor cell reservoir; the delayed engraftment after CB transplantation may reflect the difficulty of CB progenitors to reprogram themselves toward differentiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. A. Panepucci, R. T. Calado, V. Rocha, R. Proto-Siqueira, W. A. Silva Jr., and M. A. Zago Higher Expression of Transcription Targets and Components of the Nuclear Factor-{kappa}B Pathway Is a Distinctive Feature of Umbilical Cord Blood CD34+ Precursors Stem Cells, January 1, 2007; 25(1): 189 - 196. [Abstract] [Full Text] [PDF] T. Jaatinen, H. Hemmoranta, S. Hautaniemi, J. Niemi, D. Nicorici, J. Laine, O. Yli-Harja, and J. Partanen Global Gene Expression Profile of Human Cord Blood-Derived CD133+ Cells Stem Cells, March 1, 2006; 24(3): 631 - 641. [Abstract] [Full Text] [PDF] T. Lapidot, A. Dar, and O. Kollet How do stem cells find their way home? Blood, September 15, 2005; 106(6): 1901 - 1910. [Abstract] [Full Text] [PDF] Y. Kosaka, K. Koh, N. Kinukawa, Y. Wakazono, K. Isoyama, T. Oda, Y. Hayashi, S. Ohta, H. Moritake, M. Oda, et al. Infant acute lymphoblastic leukemia with MLL gene rearrangements: outcome following intensive chemotherapy and hematopoietic stem cell transplantation Blood, December 1, 2004; 104(12): 3527 - 3534. [Abstract] [Full Text] [PDF] V. Rocha, M. Labopin, G. Sanz, W. Arcese, R. Schwerdtfeger, A. Bosi, N. Jacobsen, T. Ruutu, M. de Lima, J. Finke, et al. Transplants of Umbilical-Cord Blood or Bone Marrow from Unrelated Donors in Adults with Acute Leukemia N. Engl. J. Med., November 25, 2004; 351(22): 2276 - 2285. [Abstract] [Full Text] [PDF] E. J. Gang, J. A. Jeong, S. H. Hong, S. H. Hwang, S. W. Kim, I. H. Yang, C. Ahn, H. Han, and H. Kim Skeletal Myogenic Differentiation of Mesenchymal Stem Cells Isolated from Human Umbilical Cord Blood Stem Cells, July 1, 2004; 22(4): 617 - 624. [Abstract] [Full Text] [PDF] F. Fiorentino, A. Biricik, H. Karadayi, H. Berkil, G. Karlikaya, S. Sertyel, D. Podini, M. Baldi, M.C. Magli, L. Gianaroli, et al. Development and clinical application of a strategy for preimplantation genetic diagnosis of single gene disorders combined with HLA matching Mol. Hum. Reprod., June 1, 2004; 10(6): 445 - 460. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020