SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on April 10, 2003; DOI 10.1182/blood-2003-01-0324. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-01-0324v1 102/3/953    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gruber, A. Articles by Hanson, S. R. Search for Related Content PubMed PubMed Citation Articles by Gruber, A. Articles by Hanson, S. R. Related Collections Hemostasis, Thrombosis, and Vascular Biology Cell Adhesion and Motility Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2003, Vol. 102, No. 3, pp. 953-955 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report Factor XI–dependence of surface- and tissue factor–initiated thrombus propagation in primates András Gruber, and Stephen R. Hanson From the Department of Biomedical Engineering at Georgia Institute of Technology & Emory University School of Medicine, Atlanta, GA; and the Yerkes National Primate Research Center, Atlanta, GA Thrombin, generated through activation of factor XI (FXI) and/or tissue factor (TF)–factor VIIa, is essential for thrombosis and hemostasis. We investigated the role of FXI-dependent thrombus propagation under arterial flow conditions producing rapid thrombus growth that, after the initiation phase, could limit the availability of TF at the blood/thrombus interface. Thrombosis was initiated by knitted dacron or TF-presenting teflon grafts deployed into arteriovenous shunts in baboons treated with antihuman FXI antibody (aFXI). Although aFXI did not prevent thrombus initiation, it markedly reduced intraluminal thrombus growth on both surfaces. The antithrombotic effect of aFXI was comparable with that of heparin at doses that significantly prolonged the partial thromboplastin time (APTT), prothrombin time (PT), and bleeding time (BT). aFXI also prolonged the APTT, but the PT and BT were unaffected. Thus, antithrombotic targeting of FXI might inhibit thrombosis with relatively modest hemostatic impairment versus strategies targeting other coagulation factors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. C. White-Adams, M. A. Berny, E. I. Tucker, J. M. Gertz, D. Gailani, R. T. Urbanus, P. G. de Groot, A. Gruber, and O. J.T. McCarty Identification of Coagulation Factor XI as a Ligand for Platelet Apolipoprotein E Receptor 2 (ApoER2) Arterioscler Thromb Vasc Biol, October 1, 2009; 29(10): 1602 - 1607. [Abstract] [Full Text] [PDF] E. I. Tucker, U. M. Marzec, T. C. White, S. Hurst, S. Rugonyi, O. J. T. McCarty, D. Gailani, A. Gruber, and S. R. Hanson Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI Blood, January 22, 2009; 113(4): 936 - 944. [Abstract] [Full Text] [PDF] O. Salomon, D. M. Steinberg, N. Koren-Morag, D. Tanne, and U. Seligsohn Reduced incidence of ischemic stroke in patients with severe factor XI deficiency Blood, April 15, 2008; 111(8): 4113 - 4117. [Abstract] [Full Text] [PDF] D. Gailani and T. Renne Intrinsic Pathway of Coagulation and Arterial Thrombosis Arterioscler Thromb Vasc Biol, December 1, 2007; 27(12): 2507 - 2513. [Abstract] [Full Text] [PDF] K. A. Tanaka, F. Szlam, H. Y. Sun, T. Taketomi, and J. H. Levy Thrombin Generation Assay and Viscoelastic Coagulation Monitors Demonstrate Differences in the Mode of Thrombin Inhibition Between Unfractionated Heparin and Bivalirudin Anesth. Analg., October 1, 2007; 105(4): 933 - 939. [Abstract] [Full Text] [PDF] U. J.H. Sachs and B. Nieswandt In Vivo Thrombus Formation in Murine Models Circ. Res., April 13, 2007; 100(7): 979 - 991. [Abstract] [Full Text] [PDF] C. J. M. Doggen, F. R. Rosendaal, and J. C. M. Meijers Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII Blood, December 15, 2006; 108(13): 4045 - 4051. [Abstract] [Full Text] [PDF] C. Kleinschnitz, G. Stoll, M. Bendszus, K. Schuh, H.-U. Pauer, P. Burfeind, C. Renne, D. Gailani, B. Nieswandt, and T. Renne Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis J. Exp. Med., March 20, 2006; 203(3): 513 - 518. [Abstract] [Full Text] [PDF] Q. Cheng, Y. Zhao, W. E. Lawson, V. V. Polosukhin, J. E. Johnson, T. S. Blackwell, and D. Gailani The effects of intrinsic pathway protease deficiencies on plasminogen-deficient mice Blood, November 1, 2005; 106(9): 3055 - 3057. [Abstract] [Full Text] [PDF] L. Jin, P. Pandey, R. E. Babine, J. C. Gorga, K. J. Seidl, E. Gelfand, D. T. Weaver, S. S. Abdel-Meguid, and J. E. Strickler Crystal Structures of the FXIa Catalytic Domain in Complex with Ecotin Mutants Reveal Substrate-like Interactions J. Biol. Chem., February 11, 2005; 280(6): 4704 - 4712. [Abstract] [Full Text] [PDF] S. M. Day, J. L. Reeve, B. Pedersen, D. M Farris, D. D. Myers, M. Im, T. W. Wakefield, N. Mackman, and W. P. Fay Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall Blood, January 1, 2005; 105(1): 192 - 198. [Abstract] [Full Text] [PDF] S. J.H. Wielders, S. Beguin, H. C. Hemker, and T. Lindhout Factor XI-Dependent Reciprocal Thrombin Generation Consolidates Blood Coagulation when Tissue Factor Is Not Available Arterioscler Thromb Vasc Biol, June 1, 2004; 24(6): 1138 - 1142. [Abstract] [Full Text] [PDF] T. Shi, G. M. Iverson, J. C. Qi, K. A. Cockerill, M. D. Linnik, P. Konecny, and S. A. Krilis {beta}2-Glycoprotein I binds factor XI and inhibits its activation by thrombin and factor XIIa: Loss of inhibition by clipped {beta}2-glycoprotein I PNAS, March 16, 2004; 101(11): 3939 - 3944. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020