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Prepublished online as a Blood First Edition Paper on April 24, 2003; DOI 10.1182/blood-2002-10-3230. This Article Full Text Full Text (PDF) All Versions of this Article: 2002-10-3230v1 102/3/996    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mele, A. Articles by Franceschi, S. Search for Related Content PubMed PubMed Citation Articles by Mele, A. Articles by Franceschi, S. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 August 2003, Vol. 102, No. 3, pp. 996-999 NEOPLASIA Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multicenter case-control study Alfonso Mele, Alessandro Pulsoni, Elvira Bianco, Pellegrino Musto, Andrè Szklo, Maria Grazia Sanpaolo, Emilio Iannitto, Amalia De Renzo, Bruno Martino, Vincenzo Liso, Cristina Andrizzi, Simona Pusterla, Fausto Dore, Maddalena Maresca, Maria Rapicetta, Fabrizio Marcucci, Franco Mandelli, and Silvia Franceschi From the Istituto Superiore di Sanità, Rome; La Sapienza University, Rome; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Casa Sollievo e Sofferenza Hospital, San Giovanni Rotondo; University of Palermo; Federico II University, Naples; Riuniti Hospital, Reggio Calabria; University of Bari; Montefiascone Hospital; Riuniti Hospital, Bergamo; University of Sassari; Catholic University, Rome, Italy; and International Agency for Research on Cancer, Lyon, France The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case series or comparisons with less than optimal control groups. This hospital-based case-control study was conducted from January 1998 through February 2001 to evaluate the association between HCV infection and B-NHL of different types. Cases were consecutive patients with a new diagnosis of B-NHL; controls were patients from other departments of the same hospitals. Both groups were interviewed using a standardized questionnaire. The prevalence of HCV infection was calculated by histologic type of B-NHL and clinical behavior (indolent or aggressive). Adjusted odds ratio (OR) and HCV-attributable risk (AR) were estimated. HCV prevalence was 17.5% among the 400 lymphoma patients and 5.6% among the 396 controls. The OR of B-NHL (patients vs controls), adjusted by age, sex, level of education, and place of birth, was 3.1 (95% confidence interval [CI], 1.8-5.2); an OR indicative of positive association was found for indolent and aggressive B-NHL. The estimated AR was 4.6%. This study confirms an association between HCV and B-NHL. In Italy, 1 of 20 instances of B-NHL may be attributable to HCV infection and may, thus, benefit from antiviral treatment. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Paulli, L. Arcaini, M. Lucioni, E. Boveri, D. Capello, F. Passamonti, M. Merli, S. Rattotti, D. Rossi, R. Riboni, et al. Subcutaneous 'lipoma-like' B-cell lymphoma associated with HCV infection: a new presentation of primary extranodal marginal zone B-cell lymphoma of MALT Ann. Onc., October 25, 2009; (2009) mdp454v1. [Abstract] [Full Text] [PDF] B Terrier, D Sene, D Saadoun, P Ghillani-Dalbin, V Thibault, A Delluc, J-C Piette, and P Cacoub Serum-free light chain assessment in hepatitis C virus-related lymphoproliferative disorders Ann Rheum Dis, January 1, 2009; 68(1): 89 - 93. [Abstract] [Full Text] [PDF] C.-Y. Hsieh, H.-H. Huang, C.-Y. Lin, L. W. Chung, Y.-M. Liao, L.-Y. Bai, and C.-F. 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