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 Prepublished online as a Blood First Edition Paper on May 8, 2003; DOI 10.1182/blood-2002-10-3264.

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Blood, 1 September 2003, Vol. 102, No. 5, pp. 1622-1625

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Brief report

Contribution of {beta}-2 microglobulin levels to the prognostic stratification of survival in patients with myelodysplastic syndrome (MDS)

Simona Gatto, Greg Ball, Francesco Onida, Hagop M. Kantarjian, Elihu H. Estey, and Miloslav Beran

From the Department of Leukemia, University of Texas M. D. Anderson Cancer Center, Houston; and the Center for Professional Excellence, The Methodist Hospital, Houston, TX.

Prospective analysis of the importance of the plasma levels of {beta}-2 microglobulin (B2M) in 553 patients with myelodysplastic syndrome (MDS) found that B2M is an independent prognostic variable for survival with weighted significance second only to the karyotype. The incorporation of the B2M covariate into risk assessment of MDS patients added significantly to the power of the IPSS to stratify MDS patients into risk categories. Our results further document that the 2 objectively measured covariates that display the highest power to predict survival, that is, karyotype and B2M, can alone be used for risk stratification. While the results must be verified in an independent and comparable population, our data strongly recommend routine measurement of B2M in patients with MDS.


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