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Prepublished online as a Blood First Edition Paper on May 15, 2003; DOI 10.1182/blood-2003-02-0448. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-02-0448v1 102/5/1634    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Scortegagna, M. Articles by Garcia, J. A. Search for Related Content PubMed PubMed Citation Articles by Scortegagna, M. Articles by Garcia, J. A. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Cell Cycle Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2003, Vol. 102, No. 5, pp. 1634-1640 HEMATOPOIESIS The HIF family member EPAS1/HIF-2 is required for normal hematopoiesis in mice Marzia Scortegagna, Margaret A. Morris, Yavuz Oktay, Michael Bennett, and Joseph A. Garcia From the Departments of Internal Medicine and Pathology, University of Texas Southwestern Medical Center (UTSWMC), Dallas. Hypoxic stress plays a role in pathophysiologic states such as myocardial infarction and cerebral vascular events as well as in normal physiologic conditions including development and hematopoiesis. Members of the hypoxia inducible factor (HIF) family function as transcriptional regulators of genes involved in the hypoxic response. After generating adult mice that globally lack endothelial PAS domain protein 1 (EPAS1, also known as HIF-2/HRF/HLF/MOP3), the second member of the HIF family, characterization of the hematopoietic cell population indicated that the loss of EPAS1/HIF-2 resulted in pancytopenia. Using bone marrow reconstitution experiments of lethally irradiated hosts, we have defined the extent and site of hematopoietic impairment in the EPAS1/HIF-2 null mice. These data suggest a critical role for EPAS1/HIF-2 in maintaining a functional microenvironment in the bone marrow for effective hematopoiesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Yamashita, O. Ohneda, A. Sakiyama, F. Iwata, K. Ohneda, and Y. Fujii-Kuriyama The microenvironment for erythropoiesis is regulated by HIF-2{alpha} through VCAM-1 in endothelial cells Blood, August 15, 2008; 112(4): 1482 - 1492. [Abstract] [Full Text] [PDF] K. Takeda, H. L. Aguila, N. S. Parikh, X. Li, K. Lamothe, L.-J. Duan, H. Takeda, F. S. Lee, and G.-H. Fong Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins Blood, March 15, 2008; 111(6): 3229 - 3235. [Abstract] [Full Text] [PDF] M. J. Percy, P. W. Furlow, G. S. Lucas, X. Li, T. R.J. Lappin, M. F. McMullin, and F. S. Lee A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis N. Engl. J. Med., January 10, 2008; 358(2): 162 - 168. [Abstract] [Full Text] [PDF] J.-P. Levesque, I. G. Winkler, J. Hendy, B. Williams, F. Helwani, V. Barbier, B. Nowlan, and S. K. Nilsson Hematopoietic Progenitor Cell Mobilization Results in Hypoxia with Increased Hypoxia-Inducible Transcription Factor-1{alpha} and Vascular Endothelial Growth Factor A in Bone Marrow Stem Cells, August 1, 2007; 25(8): 1954 - 1965. [Abstract] [Full Text] [PDF] L. Chen, K. Uchida, A. Endler, and F. Shibasaki Mammalian Tumor Suppressor Int6 Specifically Targets Hypoxia Inducible Factor 2{alpha} for Degradation by Hypoxia- and pVHL-independent Regulation J. Biol. Chem., April 27, 2007; 282(17): 12707 - 12716. [Abstract] [Full Text] [PDF] M. Gruber, C.-J. Hu, R. S. Johnson, E. J. Brown, B. Keith, and M. C. Simon Acute postnatal ablation of Hif-2{alpha} results in anemia PNAS, February 13, 2007; 104(7): 2301 - 2306. [Abstract] [Full Text] [PDF] S. M. Mense, A. Sengupta, M. Zhou, C. Lan, G. Bentsman, D. J. Volsky, and L. Zhang Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes Physiol Genomics, May 16, 2006; 25(3): 435 - 449. [Abstract] [Full Text] [PDF] K. L. Covello, J. Kehler, H. Yu, J. D. Gordan, A. M. Arsham, C.-J. Hu, P. A. Labosky, M. C. Simon, and B. Keith HIF-2{alpha} regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes & Dev., March 1, 2006; 20(5): 557 - 570. [Abstract] [Full Text] [PDF] M. J. Percy, Q. Zhao, A. Flores, C. Harrison, T. R. J. Lappin, P. H. Maxwell, M. F. McMullin, and F. S. Lee From the Cover: A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis PNAS, January 17, 2006; 103(3): 654 - 659. [Abstract] [Full Text] [PDF] P. H Maxwell Hypoxia-inducible factor as a physiological regulator Exp Physiol, November 1, 2005; 90(6): 791 - 797. [Abstract] [Full Text] [PDF] M. Scortegagna, K. Ding, Q. Zhang, Y. Oktay, M. J. Bennett, M. Bennett, J. M. Shelton, J. A. Richardson, O. Moe, and J. A. Garcia HIF-2{alpha} regulates murine hematopoietic development in an erythropoietin-dependent manner Blood, April 15, 2005; 105(8): 3133 - 3140. [Abstract] [Full Text] [PDF] C. P. Bracken, M. L. Whitelaw, and D. J. Peet Activity of Hypoxia-inducible Factor 2{alpha} Is Regulated by Association with the NF-{kappa}B Essential Modulator J. Biol. 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