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 Prepublished online as a Blood First Edition Paper on May 1, 2003; DOI 10.1182/blood-2003-03-0826.

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Blood, 1 September 2003, Vol. 102, No. 5, pp. 1743-1744

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Brief report

Decreased factor VIII levels during acetaminophen-induced murine fulminant hepatic failure

Christopher B. Doering, Ernest T. Parker, Christopher E. Nichols, and Pete Lollar

From the Winship Cancer Institute, Emory University, Atlanta, GA.

During human fulminant hepatic failure (FHF) circulating levels of most hemostatic proteins fall dramatically. Concurrently, factor VIII (fVIII) procoagulant activity rises despite destruction of the hepatocytes considered responsible for fVIII synthesis. This observation suggests a role for cells other than hepatocytes in fVIII biosynthesis during FHF. We have attempted to identify nonhepatocytic sites of fVIII biosynthesis by inducing FHF in mice using acetaminophen overdose, a common cause of human FHF. Acetaminophen-treated mice consistently displayed signs characteristic of FHF, including elevated plasma aminotransferase activity. However, acetaminophen-treated mice demonstrated markedly reduced fVIII activity, contrary to the observation in human FHF. von Willebrand factor antigen levels were only mildly reduced, suggesting that the decrease in fVIII is not secondary to loss of von Willebrand factor. These results imply that there are fundamental differences in the regulation of plasma fVIII levels between humans and mice.


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