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Prepublished online as a Blood First Edition Paper on May 8, 2003; DOI 10.1182/blood-2003-02-0578.
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Blood, 1 September 2003, Vol. 102, No. 5, pp. 1849-1856
NEOPLASIA
Identification of a gene expression signature associated with pediatric AML prognosis
Tomohito Yagi,
Akira Morimoto,
Mariko Eguchi,
Shigeyoshi Hibi,
Masahiro Sako,
Eiichi Ishii,
Shuki Mizutani,
Shinsaku Imashuku,
Misao Ohki, and
Hitoshi Ichikawa
From the Cancer Genomics Division, National Cancer Center Research
Institute, Tokyo, Japan; Department of Pediatrics, Kyoto Prefectural
University of Medicine, Japan; Leukaemia Research Fund Centre, Institute of
Cancer Research, Chester Beatty Laboratories, London, United Kingdom; Division
of Pediatrics, Osaka City General Hospital, Japan; Department of Pediatrics,
Saga Medical School, Japan; Department of Pediatrics and Developmental
Biology, Postgraduate Medical School, Tokyo Medical and Dental University,
Japan; and Kyoto City Institute of Health and Environmental Sciences,
Japan.
Most patients with acute myeloid leukemia (AML) enter complete remission
(CR) after treatment with chemotherapy, but a large number of them experience
relapse with resistant disease. To identify genes that are associated with
their prognoses, we analyzed gene expression in 54 pediatric patients with AML
using an oligonucleotide microarray that contained 12 566 probe sets. A
supervised approach using the Student t test selected a prognostic
set of 35 genes, some of which are associated with the regulation of cell
cycle and apoptosis. Most of these genes had not previously been reported to
be associated with prognosis and were not correlated with morphologically
classified French-American-British (FAB) subtypes or with karyotypes. These
results indicate the existence of prognosis-associated genes that are
independent of cell lineage and cytogenetic abnormalities, and they can
provide therapeutic direction for individual risk-adapted therapy for
pediatric AML patients.
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