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Prepublished online as a Blood First Edition Paper on May 22, 2003; DOI 10.1182/blood-2003-01-0232. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-01-0232v1 102/6/2195    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cookson, S. Articles by Reen, D. Search for Related Content PubMed PubMed Citation Articles by Cookson, S. Articles by Reen, D. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2003, Vol. 102, No. 6, pp. 2195-2197 IMMUNOBIOLOGY Brief report IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells Sharon Cookson, and Denis Reen From the Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland; and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. Expression of one or more natural killer (NK) receptors on T cells may correlate with effector function. This study investigated the frequency of neonatal NK receptor–positive (NKR+) T cells and their expansionary properties with interleukin-2 (IL-2), IL-7, or IL-15. While cord blood contains significantly decreased frequencies of NKR+ T cells compared with adult blood, newborn CD56+CD3+ cells could be expanded 200-fold during culture with IL-15. By depleting CD56+ cells, we were able to determine that this expansion was due to a subpopulation of T cells acquiring CD56 expression. Moreover, CD56 acquisition was associated with a distinct CD8+CD25+ interferon –positive (IFN-+) phenotype. This property could therefore be exploited during bone marrow reconstitution and may partially account for the resilience of the newborn to infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. P. Correia, E. M. Cardoso, C. F. Pereira, R. Neves, M. Uhrberg, and F. A. Arosa Hepatocytes and IL-15: A Favorable Microenvironment for T Cell Survival and CD8+ T Cell Differentiation J. Immunol., May 15, 2009; 182(10): 6149 - 6159. [Abstract] [Full Text] [PDF] N. L. Alves, E. M. M. van Leeuwen, E. B. M. Remmerswaal, N. Vrisekoop, K. Tesselaar, E. Roosnek, I. J. M. ten Berge, and R. A. W. van Lier A New Subset of Human Naive CD8+ T Cells Defined by Low Expression of IL-7R{alpha} J. Immunol., July 1, 2007; 179(1): 221 - 228. [Abstract] [Full Text] [PDF] T. A. Stoklasek, K. S. Schluns, and L. Lefrancois Combined IL-15/IL-15R{alpha} Immunotherapy Maximizes IL-15 Activity In Vivo J. Immunol., November 1, 2006; 177(9): 6072 - 6080. [Abstract] [Full Text] [PDF] S. A. Fadel, L. G. Cowell, S. Cao, D. A. Ozaki, T. B. Kepler, D. A. Steeber, and M. Sarzotti Neonate-primed CD8+ memory cells rival adult-primed memory cells in antigen-driven expansion and anti-viral protection Int. Immunol., February 1, 2006; 18(2): 249 - 257. [Abstract] [Full Text] [PDF] N. L. Alves, F. A. Arosa, and R. A. W. van Lier IL-21 Sustains CD28 Expression on IL-15-Activated Human Naive CD8+ T Cells J. Immunol., July 15, 2005; 175(2): 755 - 762. [Abstract] [Full Text] [PDF]

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