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Prepublished online as a Blood First Edition Paper on May 22, 2003; DOI 10.1182/blood-2003-01-0232.
Blood, 15 September 2003, Vol. 102, No. 6, pp. 2195-2197 IL-15 drives neonatal T cells to acquire CD56 and become activated effector cellsFrom the Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland; and the Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Expression of one or more natural killer (NK) receptors on T cells may correlate with effector function. This study investigated the frequency of neonatal NK receptorpositive (NKR+) T cells and their expansionary properties with interleukin-2 (IL-2), IL-7, or IL-15. While cord blood contains significantly decreased frequencies of NKR+ T cells compared with adult blood, newborn CD56+CD3+ cells could be expanded 200-fold during culture with IL-15. By depleting CD56+ cells, we were able to determine that this expansion was due to a subpopulation of T cells acquiring CD56 expression. Moreover, CD56 acquisition was associated with a distinct CD8+CD25+ interferon
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