|
|
Blood, 15 October 2003, Vol. 102, No. 8, pp. 2746-2755.
Prepublished online as a Blood First Edition Paper on July 3, 2003; DOI 10.1182/blood-2003-03-0880.
 Previous Article | Table of Contents | Next Article 
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
New score predicting for prognosis in PML-RARA+, AML1-ETO+, or CBFBMYH11+ acute myeloid leukemia based on quantification of fusion transcripts
Susanne Schnittger,
Martin Weisser,
Claudia Schoch,
Wolfgang Hiddemann,
Torsten Haferlach, and
Wolfgang Kern
From the Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig-Maximilians University of Munich, University Hospital Grosshadern, Munich, Germany; and Clinical Cooperative Group Leukemia (GSF), National Research Center for Environment and Health, Munich, Germany.
To evaluate the prognostic significance of quantitative PML-RARA, AML1-ETO, and CBFB-MYH11 fusion transcript expression, real-time polymerase chain reaction was used to analyze bone marrow samples of 349 such patients at diagnosis and 522 samples of 142 patients also during therapy (total analyses, n = 859; median number of follow-up samples, 4/patient; median duration of assessment, 12 months). Lower expression levels at diagnosis correlated with better overall and event-free survival in all 3 leukemia subtypes. By combining the median expression ratio after consolidation therapy and the 75th percentile of the expression ratio at diagnosis, a new score was established that separates a group with 100% EFS from a significantly worse group (P < .0001) in each of the 3 acute myeloid leukemia subgroups. Eight patients showed increasing levels of expression during follow-up and all had relapse. In conclusion, patients at high risk for treatment failure can be identified by high levels of fusion gene expression at diagnosis or less than 3 logs of tumor reduction during the first 3 to 4 months of therapy. By combining the transcription ratios at these 2 checkpoints, a new powerful prognostic score has been established.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Clozel, A. Renneville, M. Venot, C. Gardin, C. Kelaidi, G. Leroux, V. Eclache, C. Preudhomme, P. Fenaux, and L. Ades
Slow relapse in acute myeloid leukemia with inv(16) or t(16;16)
Haematologica,
October 1, 2009;
94(10):
1466 - 1467.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schnittger, W. Kern, C. Tschulik, T. Weiss, F. Dicker, B. Falini, C. Haferlach, and T. Haferlach
Minimal residual disease levels assessed by NPM1 mutation-specific RQ-PCR provide important prognostic information in AML
Blood,
September 10, 2009;
114(11):
2220 - 2231.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Grimwade, J. V. Jovanovic, R. K. Hills, E. A. Nugent, Y. Patel, R. Flora, D. Diverio, K. Jones, H. Aslett, E. Batson, et al.
Prospective Minimal Residual Disease Monitoring to Predict Relapse of Acute Promyelocytic Leukemia and to Direct Pre-Emptive Arsenic Trioxide Therapy
J. Clin. Oncol.,
August 1, 2009;
27(22):
3650 - 3658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Santamaria, M. C. Chillon, R. Garcia-Sanz, A. Balanzategui, M. E. Sarasquete, M. Alcoceba, F. Ramos, T. Bernal, J. A. Queizan, M. J. Penarrubia, et al.
The relevance of preferentially expressed antigen of melanoma (PRAME) as a marker of disease activity and prognosis in acute promyelocytic leukemia
Haematologica,
December 1, 2008;
93(12):
1797 - 1805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Maurillo, F. Buccisano, M. I. Del Principe, G. Del Poeta, A. Spagnoli, P. Panetta, E. Ammatuna, B. Neri, L. Ottaviani, C. Sarlo, et al.
Toward Optimization of Postremission Therapy for Residual Disease-Positive Patients With Acute Myeloid Leukemia
J. Clin. Oncol.,
October 20, 2008;
26(30):
4944 - 4951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Bacher, C. Haferlach, W. Kern, T. Haferlach, and S. Schnittger
Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients
Blood,
March 1, 2008;
111(5):
2527 - 2537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. P. S. Rawat, S. Thoene, V. M. Naidu, N. Arseni, B. Heilmeier, K. Metzeler, K. Petropoulos, A. Deshpande, L. Quintanilla-Martinez, S. K. Bohlander, et al.
Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia
Blood,
January 1, 2008;
111(1):
309 - 319.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Santamaria, M. C. Chillon, C. Fernandez, P. Martin-Jimenez, A. Balanzategui, R. Garcia Sanz, J. F. San Miguel, and M.-G. Gonzalez
Using quantification of the PML-RAR{alpha} transcript to stratify the risk of relapse in patients with acute promyelocytic leukemia
Haematologica,
March 1, 2007;
92(3):
315 - 322.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Meshinchi and R. J. Arceci
Prognostic Factors and Risk-Based Therapy in Pediatric Acute Myeloid Leukemia
Oncologist,
March 1, 2007;
12(3):
341 - 355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. P. Kalogianni, V. Bravou, T. K. Christopoulos, P. C. Ioannou, and N. C. Zoumbos
Dry-reagent disposable dipstick test for visual screening of seven leukemia-related chromosomal translocations
Nucleic Acids Res.,
February 28, 2007;
35(4):
e23 - e23.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Ghaffari, S Rostami, D Bashash, K Alimoghaddam, and A Ghavamzadeh
Real-time PCR analysis of PML-RAR{alpha} in newly diagnosed acute promyelocytic leukaemia patients treated with arsenic trioxide as a front-line therapy
Ann. Onc.,
October 1, 2006;
17(10):
1553 - 1559.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U. Bacher, T. Haferlach, C. Schoch, W. Kern, and S. Schnittger
Implications of NRAS mutations in AML: a study of 2502 patients
Blood,
May 15, 2006;
107(10):
3847 - 3853.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lapillonne, A. Renneville, A. Auvrignon, C. Flamant, A. Blaise, C. Perot, J.-L. Lai, P. Ballerini, F. Mazingue, S. Fasola, et al.
High WT1 Expression After Induction Therapy Predicts High Risk of Relapse and Death in Pediatric Acute Myeloid Leukemia
J. Clin. Oncol.,
April 1, 2006;
24(10):
1507 - 1515.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Schnittger, T. M. Kohl, T. Haferlach, W. Kern, W. Hiddemann, K. Spiekermann, and C. Schoch
KIT-D816 mutations in AML1-ETO-positive AML are associated with impaired event-free and overall survival
Blood,
March 1, 2006;
107(5):
1791 - 1799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Lo-Coco and E. Ammatuna
The Biology of Acute Promyelocytic Leukemia and Its Impact on Diagnosis and Treatment
Hematology,
January 1, 2006;
2006(1):
156 - 161.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Frohling, C. Scholl, D. G. Gilliland, and R. L. Levine
Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications
J. Clin. Oncol.,
September 10, 2005;
23(26):
6285 - 6295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Haferlach, A. Kohlmann, S. Schnittger, M. Dugas, W. Hiddemann, W. Kern, and C. Schoch
Global approach to the diagnosis of leukemia using gene expression profiling
Blood,
August 15, 2005;
106(4):
1189 - 1198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Kern, D. Voskova, C. Schoch, W. Hiddemann, S. Schnittger, and T. Haferlach
Determination of relapse risk based on assessment of minimal residual disease during complete remission by multiparameter flow cytometry in unselected patients with acute myeloid leukemia
Blood,
November 15, 2004;
104(10):
3078 - 3085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Saussoy, J.-L. Vaerman, N. Straetmans, V. Deneys, G. Cornu, A. Ferrant, and D. Latinne
Differentiation of Acute Myeloid Leukemia from B- and T-Lineage Acute Lymphoid Leukemias by Real-Time Quantitative Reverse Transcription-PCR of Lineage Marker mRNAs
Clin. Chem.,
July 1, 2004;
50(7):
1165 - 1173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-X. Shen, Z.-Z. Shi, J. Fang, B.-W. Gu, J.-M. Li, Y.-M. Zhu, J.-Y. Shi, P.-Z. Zheng, H. Yan, Y.-F. Liu, et al.
Inaugural Article: All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia
PNAS,
April 13, 2004;
101(15):
5328 - 5335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
