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Blood, 15 October 2003, Vol. 102, No. 8, pp. 2868-2876.
Prepublished online as a Blood First Edition Paper on June 26, 2003; DOI 10.1182/blood-2003-03-0692.
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IMMUNOBIOLOGY
Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology
Teresa Marafioti,
Margaret Jones,
Fabio Facchetti,
Tim C. Diss,
Ming-Qing Du,
Peter G. Isaacson,
Michela Pozzobon,
Stefano A. Pileri,
Amanda J. Strickson,
Soo-Yong Tan,
Fiona Watkins, and
David Y. Mason
From the Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; The Leukaemia Research Fund Immunodiagnostics and Molecular Haematology Units, Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom; Institute of Pathologic Anatomy, Civil Hospital, Brescia University, Brescia, Italy; Department of Histopathology, University College Medical School, London, United Kingdom; Pathologic Anatomy and Haematopathology Centre, Institute of Haematology and Clinical Oncology "L & A Seragnoli," S Orsola Polyclinic, Bologna University, Bologna, Italy; and the Department of Pathology and Laboratory Medicine, Tan Tock Seng Hospital, Tan Tock Seng, Singapore.
We describe large B cells, many of which have a stellate or dendritic morphology, found in the interfollicular T-cell–rich areas of human peripheral lymphoid tissue. These B cells probably require CD40/CD40 ligand signaling for their generation and have a unique phenotype and a post–germinal center pattern of immunoglobulin gene mutation. The only comparable B cell is the "asteroid" cell of the thymic medulla. Their anatomic location and pattern of gene mutation suggest that these cells may represent the cell of origin of some human large-cell lymphomas. Studies in experimental animals should help to elucidate the role of these cells in the immune response.
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