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Blood, 15 October 2003, Vol. 102, No. 8, pp. 3043-3051. Prepublished online as a Blood First Edition Paper on June 26, 2003; DOI 10.1182/blood-2003-03-0665. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-03-0665v1 102/8/3043    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gorin, N. C. Articles by Frassoni, F. Search for Related Content PubMed PubMed Citation Articles by Gorin, N. C. Articles by Frassoni, F. Related Collections Neoplasia Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Marrow versus peripheral blood for geno-identical allogeneic stem cell transplantation in acute myelocytic leukemia: influence of dose and stem cell source shows better outcome with rich marrow Norbert C. Gorin, Myriam Labopin, Vanderson Rocha, William Arcese, Meral Beksac, Eliane Gluckman, Olle Ringden, Tapani Ruutu, Josy Reiffers, Giuseppe Bandini, Michele Falda, Panagiotis Zikos, Roelf Willemze, and Francesco Frassoni, for the Acute Leukemia Working Party (ALWP) of the European Cooperative Group for Blood and Marrow Transplantation (EBMT) From the Centre international greffes de moelle, Hopital Saint-Antoine, AP-HP, European Data Management Office of the EBMT, UPRES EA 1638, and Centre de recherche Claude Bernard sur la thérapie cellulaire, Université Paris VI, Paris, France; Hôpital St Louis, Paris, France; Universita La Sapienza, Rome, Italy; Ibni Sina Hospital, Ankara, Turkey; Huddinge University Hospital, Stockholm, Sweden; Helsinki University Central Hospital, Finland; Hôpital Haut-Lévêque, Pessac, France; Hospital San Orsola, Bologna, Italy; Azienda Ospedaliera S. Giovanni, Torino, Italy; Patras University Medical School, Patras, Greece; Leiden University Hospital, the Netherlands; and Ospedale San Martino, Genova, Italy. Several studies have compared bone marrow (BM) and peripheral blood (PB) as stem cell sources in patients receiving allografts, but the cell doses infused have not been considered, especially for BM. Using the ALWP/EBMT registry, we retrospectively studied 881 adult patients with acute myelocytic leukemia (AML), who received a non–T-depleted allogeneic BM (n = 515) or mobilized PB (n = 366) standard transplant, in first remission (CR1), from an HLA-identical sibling, over a 5-year period from January 1994. The BM cell dose ranged from 0.17 to 29 x 108/kg with a median of 2.7 x 108/kg. The PB cell dose ranged from 0.02 to 77 x 108/kg with a median of 9.3 x 108/kg. The median dose for patients receiving BM (2.7 x 108/kg) gave the greatest discrimination. In multivariate analyses, high-dose BM compared to PB was associated with lower transplant-related mortality (RR = 0.61; 95% CI, 0.39-0.98; P = .04), better leukemia-free survival (RR = 0.65; 95% CI, 0.46-0.91; P = .013), and better overall survival (RR = 0.64; 95% CI, 0.44-0.92; P = .016). The present study in patients with AML receiving allografts in first remission indicates a better outcome with BM as compared to PB, when the dose of BM infused is rich. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Morra, G. Barosi, A. Bosi, F. Ferrara, F. Locatelli, M. Marchetti, G. Martinelli, C. Mecucci, M. Vignetti, and S. Tura Clinical management of primary non-acute promyelocytic leukemia acute myeloid leukemia: practice Guidelines by the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation Haematologica, January 1, 2009; 94(1): 102 - 112. [Abstract] [Full Text] [PDF] N.-C. Gorin, M. Labopin, J.-M. Boiron, N. Theorin, T. Littlewood, S. Slavin, H. Greinix, J. Y. Cahn, E. P. Alessandrino, A. Rambaldi, et al. Results of Genoidentical Hemopoietic Stem Cell Transplantation With Reduced Intensity Conditioning for Acute Myelocytic Leukemia: Higher Doses of Stem Cells Infused Benefit Patients Receiving Transplants in Second Remission or Beyond--The Acute Leukemia Working Party of the European Cooperative Group for Blood and Marrow Transplantation J. Clin. Oncol., August 20, 2006; 24(24): 3959 - 3966. [Abstract] [Full Text] [PDF] D.-P. Lu, L. Dong, T. Wu, X.-J. Huang, M.-J. Zhang, W. Han, H. Chen, D.-H. Liu, Z.-Y. Gao, Y.-H. Chen, et al. Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation Blood, April 15, 2006; 107(8): 3065 - 3073. [Abstract] [Full Text] [PDF] D. A. Wall Allogeneic Peripheral Blood Versus Bone Marrow Transplantation: Children Are Small Adults and More J. Clin. Oncol., December 15, 2004; 22(24): 4865 - 4866. [Full Text] [PDF]

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