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Blood, 1 November 2003, Vol. 102, No. 9, pp. 3420-3426.
Prepublished online as a Blood First Edition Paper on July 17, 2003; DOI 10.1182/blood-2003-05-1448.
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RED CELLS
Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites
Theodore F. Taraschi,
Megan O'Donnell,
Sandra Martinez,
Timothy Schneider,
Darin Trelka,
Velia M. Fowler,
Leann Tilley, and
Yoshinori Moriyama
From the Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA; Department of Cell Biology, The Scripps Research Institute, La Jolla, CA; Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia; and Department of Biochemistry, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite-encoded proteins to the erythrocyte plasma membrane. Activation of G proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane.
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