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Blood, 15 May 2004, Vol. 103, No. 10, pp. 3624-3634.
Prepublished online as a Blood First Edition Paper on January 15, 2004; DOI 10.1182/blood-2003-09-3295.
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REVIEW ARTICLES
Proteomics techniques and their application to hematology
Ileana M. Cristea,
Simon J. Gaskell, and
Anthony D. Whetton
From the Michael Barber Centre for Mass Spectrometry, Department of Chemistry, University of Manchester Institute of Science and Technology (UMIST), Manchester, United Kingdom; Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, New York, NY; Leukaemia Research Fund Proteomics Facility, Department of Biomolecular Sciences, UMIST, Manchester, United Kingdom; and Paterson Institute for Cancer Research, Christie Hospital, Withington, Manchester, United Kingdom.
The recent sequencing of a number of genomes has raised the level of opportunities for studies on proteins. This area of research has been described with the all-embracing term, proteomics. In proteomics, the use of mass spectrometric techniques enables genomic databases to be used to establish the identity of proteins with relatively little data, compared to the era before genome sequencing. The use of related analytical techniques also offers the opportunity to gain information on regulation, via posttranslational modification, and potential new diagnostic and prognostic indicators. Relative quantification of proteins and peptides in cellular and extracellular material remains a challenge for proteomics and mass spectrometry. This review presents an analysis of the present and future impact of these proteomic technologies with emphasis on relative quantification for hematologic research giving an appraisal of their potential benefits.
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