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Blood, 15 May 2004, Vol. 103, No. 10, pp. 3805-3812. Prepublished online as a Blood First Edition Paper on December 30, 2003; DOI 10.1182/blood-2003-09-3109. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3109v1 103/10/3805    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ellyard, J. I. Articles by Tangye, S. G. Search for Related Content PubMed PubMed Citation Articles by Ellyard, J. I. Articles by Tangye, S. G. Related Collections Immunobiology Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow Julia I. Ellyard, Danielle T. Avery, Tri Giang Phan, Nathan J. Hare, Philip D. Hodgkin, and Stuart G. Tangye From the Centenary Institute of Cancer Medicine and Cell Biology, Newtown, New South Wales, Australia; the University of Sydney, New South Wales, Australia; and the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. Plasma cells (PCs) represent the final stage of B-cell differentiation and are devoted to the production of immunoglobulin (Ig). Perturbations to their development can result in human disorders characterized by PC expansion and hypergammaglobulinemia. Ig-secreting cells (ISCs) have been identified in secondary lymphoid tissues and bone marrow (BM). Most ISCs in lymphoid tissue are short-lived; in contrast, ISCs that migrate to the BM become long-lived PCs and continue to secrete immunoglobulin for extended periods. However, a small population of long-lived PCs has been identified in rodent spleen, suggesting that PCs may persist in secondary lymphoid tissue and that the spleen, as well as the BM, plays an important role in maintaining long-term humoral immunity. For these reasons, we examined ISCs in human spleen and identified a population that appears analogous to long-lived rodent splenic PCs. Human splenic ISCs shared morphologic, cellular, molecular, and functional characteristics with long-lived PCs in BM, demonstrating their commitment to the PC lineage. Furthermore, the detection of highly mutated immunoglobulin V region genes in splenic ISCs suggested they are likely to be antigen-selected and to secrete high-affinity immunoglobulin. Thus, our results suggest that splenic ISCs have an important role in humoral immunity and may represent the affected cell type in some B-cell dyscrasias. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Solomon, S. D. Macy, C. Wooliver, D. T. Weiss, and P. Westermark Splenic plasma cells can serve as a source of amyloidogenic light chains Blood, February 12, 2009; 113(7): 1501 - 1503. [Abstract] [Full Text] [PDF] K. L. Good, D. T. Avery, and S. G. Tangye Resting Human Memory B Cells Are Intrinsically Programmed for Enhanced Survival and Responsiveness to Diverse Stimuli Compared to Naive B Cells J. Immunol., January 15, 2009; 182(2): 890 - 901. [Abstract] [Full Text] [PDF] I. Gonzalez-Garcia, B. Rodriguez-Bayona, F. Mora-Lopez, A. Campos-Caro, and J. A. 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