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 Blood, 1 June 2004, Vol. 103, No. 11, pp. 4240-4242.
Prepublished online as a Blood First Edition Paper on February 24, 2004; DOI 10.1182/blood-2003-11-3805.

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IMMUNOBIOLOGY
Brief report

Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells

Tobias R. Kollmann, Sing Sing Way, Heidi L. Harowicz, Adeline M. Hajjar, and Christopher B. Wilson

From the Departments of Pediatrics and Immunology, University of Washington School of Medicine, Seattle, WA.

Neonates respond suboptimally to many vaccines. The reasons for this defect are unclear, but suboptimal antigen presentation by dendritic cells has been suggested as one possibility. In this report we describe an in vitro system that allows the generation of large numbers of resting murine neonatal dendritic cells facilitating their study. Using this system, we show a clear reduction in the ability of neonatal dendritic cells to present soluble ovalbumin, while the capacity to present ovalbumin peptide is intact. This suggests a specific defect in cross-presentation of exogenous antigen via the major histocompatibility complex (MHC) class I pathway. Deficient cross-presentation may contribute to the suboptimal CD8 T-cell response to vaccines in neonates. (Blood. 2004;103:4240-4242)


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W. E. Walker and D. R. Goldstein
Neonatal B Cells Suppress Innate Toll-Like Receptor Immune Responses and Modulate Alloimmunity
J. Immunol., August 1, 2007; 179(3): 1700 - 1710.
[Abstract] [Full Text] [PDF]


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