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Blood, 1 June 2004, Vol. 103, No. 11, pp. 4330-4335. Prepublished online as a Blood First Edition Paper on February 12, 2004; DOI 10.1182/blood-2003-09-3325. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3325v1 103/11/4330    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Reddy, V. Articles by Wingard, J. R. Search for Related Content PubMed PubMed Citation Articles by Reddy, V. Articles by Wingard, J. R. Related Collections Immunobiology Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host disease Vijay Reddy, Jose A. Iturraspe, Alessandra C. Tzolas, Herwig-Ulf Meier-Kriesche, Jesse Schold, and John R. Wingard From the University of Florida College of Medicine, Gainesville; and LifeSouth Community Blood Centers, Gainesville, FL. Dendritic cells (DCs) are key antigen-presenting cells with a potential role in tumor vaccines. We investigated the hypothesis that early reconstitution of DCs after allogeneic hematopoietic stem cell transplantation (SCT) improves survival. We also correlated DC reconstitution with complications of relapse and acute graft-versus-host disease (aGVHD). Fifty patients underwent transplantation between February 2000 and March 2003, with a median follow-up of 501 days (range, 136-1263 days). Most (92%) received blood stem cells, and the remainder received bone marrow from HLA-matched sibling donors for predominantly high-risk hematologic malignancies. Around the time of engraftment, peripheral blood underwent flow cytometry analysis for DCs, and the cells were divided as DC1 and DC2. Using Kaplan-Meier analysis, patients with lower DC counts (< 4.97 cells/µL) were found to have significantly worse survival (P = .002), increased incidence of relapse (P = .002), higher incidence of aGVHD onset (P = .0005), and a composite end point of relapse or death (P = .0017). A Cox proportional hazards multivariate model adjusted for important covariates confirmed that low DC count is independently associated with death (hazard ratio [HR], 3.8; P = .02), time to relapse (HR, 11.6; P = .001), and aGVHD (HR, 3.3; P = .04). Sensitivity and specificity rates for low DC count in predicting death or relapse are 73% and 75%, respectively. Low numbers of circulating DCs significantly increase the risk for relapse and acute GVHD and predict death after allogeneic SCT. (Blood. 2004;103:4330-4335) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. M. Dunbar, M. P. Buzzeo, J. B. Levine, J. D. Schold, H.-U. Meier-Kriesche, and V. Reddy The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host disease Haematologica, December 1, 2008; 93(12): 1852 - 1858. [Abstract] [Full Text] [PDF] C. Talarn, A. Urbano-Ispizua, R. Martino, J. A. Perez-Simon, M. Batlle, C. Herrera, M. Granell, A. Gaya, M. Torrebadell, F. Fernandez-Aviles, et al. Kinetics of recovery of dendritic cell subsets after reduced-intensity conditioning allogeneic stem cell transplantation and clinical outcome Haematologica, December 1, 2007; 92(12): 1655 - 1663. [Abstract] [Full Text] [PDF] P. Athanassopoulos, L. M.B. Vaessen, A. H.M.M. Balk, J. J.M. Takkenberg, A. P.W.M. Maat, W. Weimar, and A. J.J.C. Bogers Impaired circulating dendritic cell reconstitution identifies rejecting recipients after clinical heart transplantation independent of rejection therapy Eur. J. Cardiothorac. Surg., May 1, 2005; 27(5): 783 - 789. [Abstract] [Full Text] [PDF] V. Reddy, A. G. Winer, E. Eksioglu, J. Levine, H.-U. Meier-Kriesche, J. Schold, H. Mossak, and J. R. Wingard High Levels of Interleukin-12 Are Associated with Reduced Incidence of Relapse and Death without Increasing Acute Graft-Versus-Host Disease (AGVHD) after Allogeneic Stem Cell Transplantation (SCT). Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 295 - 295. [Abstract] [Full Text]

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