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Blood, 15 June 2004, Vol. 103, No. 12, pp. 4429-4431.
Prepublished online as a Blood First Edition Paper on March 11, 2004; DOI 10.1182/blood-2003-11-3883.
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CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Brief report
Durable responses after ibritumomab tiuxetan radioimmunotherapy for CD20+ B-cell lymphoma: long-term follow-up of a phase 1/2 study
Leo I. Gordon,
Arturo Molina,
Thomas Witzig,
Christos Emmanouilides,
Andrew Raubtischek,
Mohamed Darif,
Russell J. Schilder,
Greg Wiseman, and
Christine A. White
From the Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, and the Robert H. Lurie Comprehensive Cancer Center, Chicago, IL; IDEC Pharmaceuticals, San Diego, CA; Mayo Clinic and Mayo Foundation, Rochester, MN; University of California, Los Angeles, CA; City of Hope Cancer Center, Duarte, CA; and Fox Chase Cancer Center, Philadelphia, PA
We previously demonstrated that yttrium-90 (Y-90) ibritumomab tiuxetan (Zevalin) radioimmunotherapy (RIT) was safe and effective for relapsed or refractory CD20+, B-cell, non-Hodgkin lymphoma (NHL). We now provide long-term follow-up data in responding patients based on International Workshop Response Criteria. Complete (CR), CR unconfirmed (CRu), and partial response (PR) rates were 29%, 22%, and 22%, respectively (overall response rate 73%, 51% in CR/CRu). Mean time to progression (TTP) and duration of response (DR) in responders were 12.6 months and 11.7 months, respectively. At the maximum tolerated dose (0.4 mCi/kg [14.8 MBq/kg]), TTP and DR in complete responders (CR/CRu) were 28.3 and 27.5 months, respectively. Nine patients (24% of responding patients) had a TTP of more than 3 years. Long-term responders (> 5 years) have been identified. Ibritumomab tiuxetan produces durable responses in patients with indolent and diffuse large B-cell lymphoma. (Blood. 2004;103:4429-4431)
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