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Blood, 15 June 2004, Vol. 103, No. 12, pp. 4457-4465.
Prepublished online as a Blood First Edition Paper on February 24, 2004; DOI 10.1182/blood-2003-08-2713.
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HEMATOPOIESIS
Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors
Emile van den Akker,
Thamar van Dijk,
Martine Parren-van Amelsvoort,
Katja S. Grossmann,
Ute Schaeper,
Kenya Toney-Earley,
Susan E. Waltz,
Bob Löwenberg, and
Marieke von Lindern
From the Department of Hematology, Erasmus MC, Rotterdam, the Netherlands; Max Delbruck Center, Berlin, Germany; and the Department of Surgery, University of Cincinnati College of Medicine, OH.
Erythropoietin (EPO) is required for cell survival during differentiation and for progenitor expansion during stress erythropoiesis. Although signaling pathways may couple directly to docking sites on the EPO receptor (EpoR), additional docking molecules expand the signaling platform of the receptor. We studied the roles of the docking molecules Grb2-associated binder-1 (Gab1) and Gab2 in EPO-induced signal transduction and erythropoiesis. Inhibitors of phosphatidylinositide 3-kinase and Src kinases suppressed EPO-dependent phosphorylation of Gab2. In contrast, Gab1 activation depends on recruitment and phosphorylation by the tyrosine kinase receptor RON, with which it is constitutively associated. RON activation induces the phosphorylation of Gab1, mitogen-activated protein kinase (MAPK), and protein kinase B (PKB) but not of signal transducer and activator of transcription 5 (Stat5). RON activation was sufficient to replace EPO in progenitor expansion but not in differentiation. In conclusion, we elucidated a novel mechanism specifically involved in the expansion of erythroblasts involving RON as a downstream target of the EpoR. (Blood. 2004;103:4457-4465)
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