SEARCH:   Advanced

Blood, 15 June 2004, Vol. 103, No. 12, pp. 4666-4668. Prepublished online as a Blood First Edition Paper on January 8, 2004; DOI 10.1182/blood-2003-09-3220. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-09-3220v1 103/12/4666    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mohty, M. Articles by Gaugler, B. Search for Related Content PubMed PubMed Citation Articles by Mohty, M. Articles by Gaugler, B. Related Collections Neoplasia Phagocytes Oncogenes and Tumor Suppressors Signal Transduction Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia Mohamad Mohty, Eric Jourdan, Naira Ben Mami, Norbert Vey, Ghandi Damaj, Didier Blaise, Daniel Isnardon, Daniel Olive, and Béatrice Gaugler From the Laboratoire d'Immunologie des Tumeurs, Institut Paoli-Calmettes, Marseille, France; Unité de Transplantation et de Thérapie Cellulaire (UTTC), Institut Paoli-Calmettes, Marseille, France; Service de Médecine Interne B, Centre Hospitalier et Universitaire (CHU) de Nimes, Nimes, France; Département d'Hématologie, Institut Paoli-Calmettes, Marseille, France; and Institut National de la Santé et de la Recherche Médicale (INSERM) U119, Marseille, France. Plasmacytoid dendritic cells (PDCs) are crucial effectors in innate immunity. In this study, we show that imatinib, a potent inhibitor of BCR/ABL tyrosine kinase activity, in the presence of Flt3-Ligand, could induce CD34+ progenitors from chronic myeloid leukemia (CML) to give rise in vitro to typical BDCA-2+ type I interferon-producing PDCs. The effect of imatinib on PDC generation was related to up-regulation of Flt3 on leukemic CD34+ progenitors. Moreover, patients with chronic myeloid leukemia (CML) who were in complete cytogenetic or molecular response after imatinib treatment restored their blood PDCs both quantitatively and functionally comparable to healthy donors, in contrast to patients not responding to imatinib, further confirming that disease response to imatinib is accompanied by restoration of PDC function in vivo. These findings provide evidence that response to imatinib is capable to restore some DC-related immune functions in CML that might be beneficial for long-term disease control. (Blood. 2004;103:4666-4668) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. I-U. Chen, H. T. Maecker, and P. P. Lee Development and dynamics of robust T-cell responses to CML under imatinib treatment Blood, June 1, 2008; 111(11): 5342 - 5349. [Abstract] [Full Text] [PDF] G. Mignot, E. Ullrich, M. Bonmort, C. Menard, L. Apetoh, J. Taieb, D. Bosisio, S. Sozzani, M. Ferrantini, J. Schmitz, et al. The Critical Role of IL-15 in the Antitumor Effects Mediated by the Combination Therapy Imatinib and IL-2 J. Immunol., May 15, 2008; 180(10): 6477 - 6483. [Abstract] [Full Text] [PDF] F. Perros, P. Dorfmuller, R. Souza, I. Durand-Gasselin, S. Mussot, M. Mazmanian, P. Herve, D. Emilie, G. Simonneau, and M. Humbert Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension Eur. Respir. J., March 1, 2007; 29(3): 462 - 468. [Abstract] [Full Text] [PDF] K. Shimizu, M. Hidaka, N. Kadowaki, N. Makita, N. Konishi, K. Fujimoto, T. Uchiyama, F. Kawano, M. Taniguchi, and S.-i. Fujii Evaluation of the Function of Human Invariant NKT Cells from Cancer Patients Using {alpha}-Galactosylceramide-Loaded Murine Dendritic Cells. J. Immunol., September 1, 2006; 177(5): 3484 - 3492. [Abstract] [Full Text] [PDF] R. Tussiwand, N. Onai, L. Mazzucchelli, and M. G. Manz Inhibition of Natural Type I IFN-Producing and Dendritic Cell Development by a Small Molecule Receptor Tyrosine Kinase Inhibitor with Flt3 Affinity J. Immunol., September 15, 2005; 175(6): 3674 - 3680. [Abstract] [Full Text] [PDF] S. Appel, S. Balabanov, T. H. Brummendorf, and P. Brossart Effects of Imatinib on Normal Hematopoiesis and Immune Activation Stem Cells, September 1, 2005; 23(8): 1082 - 1088. [Abstract] [Full Text] [PDF] Z. Li, Y. Qiao, B. Liu, E. J. Laska, P. Chakravarthi, J. M. Kulko, R. D. Bona, M. Fang, U. Hegde, V. Moyo, et al. Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia Clin. Cancer Res., June 15, 2005; 11(12): 4460 - 4468. [Abstract] [Full Text] [PDF] H. Wang, F. Cheng, A. Cuenca, P. Horna, Z. Zheng, K. Bhalla, and E. M. Sotomayor Imatinib mesylate (STI-571) enhances antigen-presenting cell function and overcomes tumor-induced CD4+ T-cell tolerance Blood, February 1, 2005; 105(3): 1135 - 1143. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020