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Blood, 15 June 2004, Vol. 103, No. 12, pp. 4681-4684. Prepublished online as a Blood First Edition Paper on January 22, 2004; DOI 10.1182/blood-2003-05-1548. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1548v1 103/12/4681    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ertault-Daneshpouy, M. Articles by Janin, A. Search for Related Content PubMed PubMed Citation Articles by Ertault-Daneshpouy, M. Articles by Janin, A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Transplantation Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease Marjan Ertault-Daneshpouy, Christophe Leboeuf, Marc Lemann, Fatiha Bouhidel, Lionel Ades, Eliane Gluckman, Gérard Socié, and Anne Janin From INSERM ERM 0220 et Université Paris VII, IFR105, Service de Pathologie, Service d'Hématologie Greffe de Moelle, and Service hépatogastro-entérologie, AP-HP, Hôpital Saint Louis, Paris, France. In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial cell alterations were found either in patients without GVHD or in nongrafted controls. In the biopsies with severe GVHD lesions, ultrastructure showed rupture of the capillary basal membrane and extravased red blood cells. These pericapillary hemorrhages were highly correlated with GVHD severity. In a separate cohort of 39 patients who underwent an allogeneic transplantation after a nonmyeloablative conditioning, 8 patients had intestinal biopsies. Three of these latter patients had both severe pathologic lesions of GVHD and similar endothelial lesions, thus, strengthening the concept that endothelial lesions are linked to GVHD severity and not to the intensity of the conditioning regimen. (Blood. 2004;103:4681-4684) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Murata, A. Janin, C. Leboeuf, J. Soulier, E. Gluckman, V. Meignin, and G. Socie Donor-derived cells and human graft-versus-host disease of the skin Blood, March 15, 2007; 109(6): 2663 - 2665. [Abstract] [Full Text] [PDF] M. Kummer, A. Lev, Y. Reiter, and B. C. Biedermann Vascular Endothelial Cells Have Impaired Capacity to Present Immunodominant, Antigenic Peptides: A Mechanism of Cell Type-Specific Immune Escape J. Immunol., February 15, 2005; 174(4): 1947 - 1953. [Abstract] [Full Text] [PDF]

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