|
|
Blood, 15 January 2004, Vol. 103, No. 2, pp. 413-421.
Prepublished online as a Blood First Edition Paper on September 22, 2003; DOI 10.1182/blood-2003-07-2412.
 Previous Article | Table of Contents | Next Article 
CHEMOKINES
Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression
Taoyong Chen,
Jun Guo,
Mingjin Yang,
Chaofeng Han,
Minghui Zhang,
Wei Chen,
Qiuyan Liu,
Jianli Wang, and
Xuetao Cao
From the Institute of Immunology, Second Military Medical University, Shanghai, China; and the Institute of Immunology, Zhejiang University, Hangzhou, China.
Migration of dendritic cells (DCs) into tissues and secondary lymphoid organs plays a crucial role in the initiation of innate and adaptive immunity. In this article, we show that cyclosporin A (CsA) impairs the migration of DCs both in vitro and in vivo. Exposure of DCs to clinical concentrations of CsA neither induces apoptosis nor alters development but does impair cytokine secretion, chemokine receptor expression, and migration. In vitro, CsA impairs the migration of mouse bone marrow–derived DCs toward macrophage inflammatory protein-3 (MIP-3) and induces them to retain responsiveness to MIP-1 after lipopolysaccharide (LPS)–stimulated DC maturation, while in vivo administration of CsA inhibits the migration of DCs out of skin and into the secondary lymphoid organs. CsA impairs chemokine receptor and cyclooxygenase-2 (COX-2) expression normally triggered in LPS-stimulated DCs; administration of exogenous prostaglandin E2 (PGE2) reverses the effects of CsA on chemokine receptor expression and DC migration. Inhibition of nuclear factor– B (NF-B) and mitogen-activated protein kinase (MAPK) pathway signaling by CsA may be responsible for the CsA-mediated effects on the regulation of chemokine receptor and cyclooxygenase-2 (COX-2) expression. Impairment of DC migration due to inhibition of PGE2 production and regulation of chemokine receptor expression may contribute, in part, to CsA-mediated immunosuppression.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. F. Gerberick, J. A. Troutman, L. M. Foertsch, J. D. Vassallo, M. Quijano, R. L. M. Dobson, C. Goebel, and J.-P. Lepoittevin
Investigation of Peptide Reactivity of Pro-hapten Skin Sensitizers Using a Peroxidase-Peroxide Oxidation System
Toxicol. Sci.,
November 1, 2009;
112(1):
164 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, Q. Liu, M. Zhang, Y. Yu, X. Liu, and X. Cao
Fas Signal Promotes Lung Cancer Growth by Recruiting Myeloid-Derived Suppressor Cells via Cancer Cell-Derived PGE2
J. Immunol.,
March 15, 2009;
182(6):
3801 - 3808.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Han, T. Chen, M. Yang, N. Li, H. Liu, and X. Cao
Human SCAMP5, a Novel Secretory Carrier Membrane Protein, Facilitates Calcium-Triggered Cytokine Secretion by Interaction with SNARE Machinery
J. Immunol.,
March 1, 2009;
182(5):
2986 - 2996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Wang, T. Chen, N. Zhang, M. Yang, B. Li, X. Lu, X. Cao, and C. Ling
Melittin, a Major Component of Bee Venom, Sensitizes Human Hepatocellular Carcinoma Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)-induced Apoptosis by Activating CaMKII-TAK1-JNK/p38 and Inhibiting I{kappa}B{alpha} Kinase-NF{kappa}B
J. Biol. Chem.,
February 6, 2009;
284(6):
3804 - 3813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Chen, J. Guo, C. Han, M. Yang, and X. Cao
Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway
J. Immunol.,
February 1, 2009;
182(3):
1449 - 1459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Valera, N. Fernandez, A. G. Trinidad, S. Alonso, G. D. Brown, A. Alonso, and M. S. Crespo
Costimulation of Dectin-1 and DC-SIGN Triggers the Arachidonic Acid Cascade in Human Monocyte-Derived Dendritic Cells
J. Immunol.,
April 15, 2008;
180(8):
5727 - 5736.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-H. Zhou, L. Dong, M.-R. Du, X.-Y. Zhu, and D.-J. Li
Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4
Reproduction,
March 1, 2008;
135(3):
385 - 395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Aki, Y. Minoda, H. Yoshida, S. Watanabe, R. Yoshida, G. Takaesu, T. Chinen, T. Inaba, M. Hikida, T. Kurosaki, et al.
Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells.
Genes Cells,
February 1, 2008;
13(2):
199 - 208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Pan, C. Luo, R. Li, A. Qiao, L. Zhang, M. Mines, A. M. Nyanda, J. Zhang, and G.-H. Fan
Cyclophilin A Is Required for CXCR4-mediated Nuclear Export of Heterogeneous Nuclear Ribonucleoprotein A2, Activation and Nuclear Translocation of ERK1/2, and Chemotactic Cell Migration
J. Biol. Chem.,
January 4, 2008;
283(1):
623 - 637.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Liu, W. Ye, G. Guan, Z. Dong, Z. Jia, and T. Yang
Developmental regulation of calcineurin isoforms in the rodent kidney: association with COX-2
Am J Physiol Renal Physiol,
December 1, 2007;
293(6):
F1898 - F1904.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W.-H. Zhou, M.-R. Du, L. Dong, X.-Y. Zhu, J.-Y. Yang, Y.-Y. He, and D.-J. Li
Cyclosporin A increases expression of matrix metalloproteinase 9 and 2 and invasiveness in vitro of the first-trimester human trophoblast cells via the mitogen-activated protein kinase pathway
Hum. Reprod.,
October 1, 2007;
22(10):
2743 - 2750.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Wang, T. Chen, C. Han, D. He, H. Liu, H. An, Z. Cai, and X. Cao
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
Blood,
August 1, 2007;
110(3):
962 - 971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-R. Du, L. Dong, W.-H. Zhou, F.-T. Yan, and D.-J. Li
Cyclosporin A Improves Pregnancy Outcome by Promoting Functions of Trophoblasts and Inducing Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings in the Mouse
Biol Reprod,
May 1, 2007;
76(5):
906 - 914.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Qian, X. Jiang, H. An, Y. Yu, Z. Guo, S. Liu, H. Xu, and X. Cao
TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation
Blood,
October 1, 2006;
108(7):
2307 - 2315.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Wang, Y. Liu, J. Wang, G. Ding, W. Zhang, G. Chen, M. Zhang, S. Zheng, and X. Cao
Induction of Allospecific Tolerance by Immature Dendritic Cells Genetically Modified to Express Soluble TNF Receptor
J. Immunol.,
August 15, 2006;
177(4):
2175 - 2185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Tang, Z. Guo, M. Zhang, J. Wang, G. Chen, and X. Cao
Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10
Blood,
August 15, 2006;
108(4):
1189 - 1197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Giordano, D. M. Magaletti, and E. A. Clark
Nitric oxide and cGMP protein kinase (cGK) regulate dendritic-cell migration toward the lymph-node-directing chemokine CCL19
Blood,
February 15, 2006;
107(4):
1537 - 1545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Chen, T. Murakami, J. J. Oppenheim, and O. M. Z. Howard
Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking
Blood,
October 1, 2005;
106(7):
2409 - 2416.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Colgan, M. Asmal, B. Yu, and J. Luban
Cyclophilin A-Deficient Mice Are Resistant to Immunosuppression by Cyclosporine
J. Immunol.,
May 15, 2005;
174(10):
6030 - 6038.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
