SEARCH:   Advanced

Blood, 15 January 2004, Vol. 103, No. 2, pp. 479-485. Prepublished online as a Blood First Edition Paper on September 25, 2003; DOI 10.1182/blood-2003-05-1686. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1686v1 103/2/479    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rowe, J. M. Articles by Wiernik, P. H. Search for Related Content PubMed PubMed Citation Articles by Rowe, J. M. Articles by Wiernik, P. H. Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group Jacob M. Rowe, Donna Neuberg, William Friedenberg, John M. Bennett, Elisabeth Paietta, Adel Z. Makary, Jane L. Liesveld, Camille N. Abboud, Gordon Dewald, F. Ann Hayes, Martin S. Tallman, and Peter H. Wiernik From the Rambam Medical Center and Technion, Haifa, Israel; Dana Farber Cancer Institute, Boston, MA; Guthrie Medical Center, Sayre, PA; University of Rochester Cancer Center, Rochester, NY; Our Lady of Mercy Cancer Center, New York Medical College, Bronx, NY; Geisinger Medical Center, Danville, PA; Mayo Clinic, Rochester, MN; Immunex Corp, Seattle, WA; and Northwestern University Feinberg School of Medicine, Chicago, IL. The optimal induction for older adults with acute myeloid leukemia (AML) is unknown. Several anthracyclines have been proposed, but the data remain equivocal. Additionally, few prospective trials of priming with hematopoietic growth factors to cycle leukemia cells prior to induction chemotherapy have been conducted. Three hundred and sixty-two older adults with previously untreated AML were randomized to either daunorubicin, idarubicin or mitoxantrone with a standard dose of cytarabine as induction therapy. In addition, 245 patients were also randomized to receive granulocyte-macrophage colony-stimulating factor (GM-CSF) or placebo beginning 2 days prior to induction chemotherapy and continuing until marrow aplasia. No difference was observed in the disease-free overall survival or in toxicity among patients receiving any of the 3 induction regimens or among those receiving growth factor or placebo for priming. However, the complete remission rate for the first 113 analyzable patients, who did not participate in the priming study and started induction therapy 3 to 5 days earlier than those who did, was significantly higher (50% versus 38%; P = .03). None of the anthracyclines is associated with improved outcome in older adults. Priming with hematopoietic growth factor did not improve response when compared with placebo. Furthermore, delaying induction therapy in older adults may lead to a lower complete remission rate. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Mandelli, M. Vignetti, S. Suciu, R. Stasi, M.-C. Petti, G. Meloni, P. Muus, F. Marmont, J.-P. Marie, B. Labar, et al. Daunorubicin Versus Mitoxantrone Versus Idarubicin As Induction and Consolidation Chemotherapy for Adults With Acute Myeloid Leukemia: The EORTC and GIMEMA Groups Study AML-10 J. Clin. Oncol., November 10, 2009; 27(32): 5397 - 5403. [Abstract] [Full Text] [PDF] E. Estey Do commonly used clinical trial designs reflect clinical reality? Haematologica, October 1, 2009; 94(10): 1435 - 1439. [Abstract] [Full Text] [PDF] B. Lowenberg, G. J. Ossenkoppele, W. van Putten, H. C. Schouten, C. Graux, A. Ferrant, P. Sonneveld, J. Maertens, M. Jongen-Lavrencic, M. von Lilienfeld-Toal, et al. High-Dose Daunorubicin in Older Patients with Acute Myeloid Leukemia N. Engl. J. Med., September 24, 2009; 361(13): 1235 - 1248. [Abstract] [Full Text] [PDF] G. Juliusson, P. Antunovic, A. Derolf, S. Lehmann, L. Mollgard, D. Stockelberg, U. Tidefelt, A. Wahlin, and M. Hoglund Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry Blood, April 30, 2009; 113(18): 4179 - 4187. [Abstract] [Full Text] [PDF] H. D. Klepin and L. Balducci Acute Myelogenous Leukemia in Older Adults Oncologist, March 1, 2009; 14(3): 222 - 232. [Abstract] [Full Text] [PDF] M. A. Sekeres, P. Elson, M. E. Kalaycio, A. S. Advani, E. A. Copelan, S. Faderl, H. M. Kantarjian, and E. Estey Time from diagnosis to treatment initiation predicts survival in younger, but not older, acute myeloid leukemia patients Blood, January 1, 2009; 113(1): 28 - 36. [Abstract] [Full Text] [PDF] J. J Kishel and J. Sivik Breakthrough invasive fungal infection in an immunocompromised host while on posaconazole prophylaxis: an omission in patient counseling and follow-up Journal of Oncology Pharmacy Practice, December 1, 2008; 14(4): 189 - 193. [Abstract] [PDF] M. A. Sekeres Treatment of older adults with acute myeloid leukemia: state of the art and current perspectives Haematologica, December 1, 2008; 93(12): 1769 - 1772. [Full Text] [PDF] J.-V. Malfuson, A. Etienne, P. Turlure, T. de Revel, X. Thomas, N. Contentin, C. Terre, S. Rigaudeau, D. Bordessoule, N. Vey, et al. Risk factors and decision criteria for intensive chemotherapy in older patients with acute myeloid leukemia Haematologica, December 1, 2008; 93(12): 1806 - 1813. [Abstract] [Full Text] [PDF] M. R. Baer, S. L. George, M. A. Caligiuri, B. L. Sanford, S. M. Bothun, K. Mrozek, J. E. Kolitz, B. L. Powell, J. O. Moore, R. M. Stone, et al. Low-Dose Interleukin-2 Immunotherapy Does Not Improve Outcome of Patients Age 60 Years and Older With Acute Myeloid Leukemia in First Complete Remission: Cancer and Leukemia Group B Study 9720 J. Clin. Oncol., October 20, 2008; 26(30): 4934 - 4939. [Abstract] [Full Text] [PDF] C. Gardin, P. Turlure, T. Fagot, X. Thomas, C. Terre, N. Contentin, E. Raffoux, S. de Botton, C. Pautas, O. Reman, et al. Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy:results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial Blood, June 15, 2007; 109(12): 5129 - 5135. [Abstract] [Full Text] [PDF] E. Estey Acute Myeloid Leukemia and Myelodysplastic Syndromes in Older Patients J. Clin. Oncol., May 10, 2007; 25(14): 1908 - 1915. [Abstract] [Full Text] [PDF] H. P. Erba Prognostic Factors in Elderly Patients with AML and the Implications for Treatment Hematology, January 1, 2007; 2007(1): 420 - 428. [Abstract] [Full Text] [PDF] S. Frohling, R. F. Schlenk, S. Kayser, M. Morhardt, A. Benner, K. Dohner, H. Dohner, and for the German-Austrian AML Study Group Cytogenetics and age are major determinants of outcome in intensively treated acute myeloid leukemia patients older than 60 years: results from AMLSG trial AML HD98-B Blood, November 15, 2006; 108(10): 3280 - 3288. [Abstract] [Full Text] [PDF] S. Palmieri, A. M. D'Arco, M. Celentano, G. Mele, C. Califano, F. Pollio, M. R. D'Amico, and F. Ferrara An antecedent diagnosis of refractory anemia with excess blasts has no prognostic relevance in acute myeloid leukemia of older adult patients Ann. Onc., July 1, 2006; 17(7): 1146 - 1151. [Abstract] [Full Text] [PDF] S. Faderl, S. Verstovsek, J. Cortes, F. Ravandi, M. Beran, G. Garcia-Manero, A. Ferrajoli, Z. Estrov, S. O'Brien, C. Koller, et al. Clofarabine and cytarabine combination as induction therapy for acute myeloid leukemia (AML) in patients 50 years of age or older Blood, July 1, 2006; 108(1): 45 - 51. [Abstract] [Full Text] [PDF] S. S. Farag, K. J. Archer, K. Mrozek, A. S. Ruppert, A. J. Carroll, J. W. Vardiman, M. J. Pettenati, M. R. Baer, M. B. Qumsiyeh, P. R. Koduru, et al. Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461 Blood, July 1, 2006; 108(1): 63 - 73. [Abstract] [Full Text] [PDF] W. Stock Controversies in Treatment of AML: Case-based Discussion Hematology, January 1, 2006; 2006(1): 185 - 191. [Abstract] [Full Text] [PDF] M. S. Tallman, D. G. Gilliland, and J. M. Rowe Drug therapy for acute myeloid leukemia Blood, August 15, 2005; 106(4): 1154 - 1163. [Abstract] [Full Text] [PDF] C.-C. Chen, C.-F. Yang, M.-H. Yang, K.-D. Lee, W.-K. Kwang, J.-Y. You, Y.-B. Yu, C.-H. Ho, C.-H. Tzeng, W.-K. Chau, et al. Pretreatment prognostic factors and treatment outcome in elderly patients with de novo acute myeloid leukemia Ann. Onc., August 1, 2005; 16(8): 1366 - 1373. [Abstract] [Full Text] [PDF] S. Amadori, S. Suciu, U. Jehn, R. Stasi, X. Thomas, J.-P. Marie, P. Muus, F. Lefrere, Z. Berneman, G. Fillet, et al. Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study Blood, July 1, 2005; 106(1): 27 - 34. [Abstract] [Full Text] [PDF] G. Bug, H. Gul, K. Schwarz, H. Pfeifer, M. Kampfmann, X. Zheng, T. Beissert, S. Boehrer, D. Hoelzer, O. G. Ottmann, et al. Valproic Acid Stimulates Proliferation and Self-renewal of Hematopoietic Stem Cells Cancer Res., April 1, 2005; 65(7): 2537 - 2541. [Abstract] [Full Text] [PDF] M. Darmon and E. Azoulay Prognosis of Acute Monocytic Leukemia (French-American-British Classification M5) J. Clin. Oncol., February 20, 2005; 23(6): 1327 - 1327. [Full Text] [PDF] E. H. Estey, X.-M. Wang, P. Thall, S. Pierce, C. Koller, S. Faderl, S. Verstovsek, J. Cortes, G. Garcia-Manero, and H. Kantarjian Plausibility of Delaying Induction Therapy in Untreated AML. Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 879 - 879. [Abstract] D. Rosenblum and S. Hirschfeld Threshold of Credibility: New Approach to Licensing Acute Leukemia Therapy. Blood (ASH Annual Meeting Abstracts), November 16, 2004; 104(11): 3128 - 3128. [Abstract] M. S. Tallman, H. T. Kim, E. Paietta, J. M. Bennett, G. Dewald, P. A. Cassileth, P. H. Wiernik, and J. M. Rowe Acute Monocytic Leukemia (French-American-British classification M5) Does Not Have a Worse Prognosis Than Other Subtypes of Acute Myeloid Leukemia: A Report From the Eastern Cooperative Oncology Group J. Clin. Oncol., April 1, 2004; 22(7): 1276 - 1286. [Abstract] [Full Text] [PDF] R. M. Stone, M. R. O'Donnell, and M. A. Sekeres Acute Myeloid Leukemia Hematology, January 1, 2004; 2004(1): 98 - 117. [Abstract] [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020