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Blood, 15 January 2004, Vol. 103, No. 2, pp. 489-491. Prepublished online as a Blood First Edition Paper on August 21, 2003; DOI 10.1182/blood-2003-07-2420. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-07-2420v1 103/2/489    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ooi, J. Articles by Asano, S. Search for Related Content PubMed PubMed Citation Articles by Ooi, J. Articles by Asano, S. Related Collections Immunobiology Transplantation Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Brief report Unrelated cord blood transplantation for adult patients with de novo acute myeloid leukemia Jun Ooi, Tohru Iseki, Satoshi Takahashi, Akira Tomonari, Kashiya Takasugi, Yoko Shimohakamada, Toshiki Yamada, Koji Ishii, Nobuhiro Ohno, Fumitaka Nagamura, Kaoru Uchimaru, Arinobu Tojo, and Shigetaka Asano From the Department of Hematology and Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. We report the results of unrelated cord blood transplantation (CBT) for 18 adult patients with de novo acute myeloid leukemia (AML). The median age was 43 years, the median weight was 55.2 kg, and the median number of cryopreserved nucleated cells was 2.51 x 107/kg. Seventeen patients had myeloid reconstitution and the median time to more than 0.5 x 109/L absolute neutrophil count was 23 days. A self-sustained platelet count more than 50 x 109/L was achieved in 16 patients at a median time of 49 days. Acute graft-versus-host disease (GVHD) above grade II occurred in 11 of 17 evaluable patients and chronic GVHD occurred in 14 of 17 evaluable patients. Fourteen patients are alive and free of disease at between 185 and 1332 days after transplantation. The probability of disease-free survival at 2 years was 76.6%. These results suggest that adult AML patients without suitable related or unrelated bone marrow donors should be considered as candidates for CBT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. G. Brunstein, J. N. Barker, D. J. Weisdorf, T. E. DeFor, J. S. Miller, B. R. Blazar, P. B. McGlave, and J. E. Wagner Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease Blood, October 15, 2007; 110(8): 3064 - 3070. [Abstract] [Full Text] [PDF] Section on Hematology/Oncology and Section on Alle Cord Blood Banking for Potential Future Transplantation Pediatrics, January 1, 2007; 119(1): 165 - 170. [Abstract] [Full Text] [PDF] N. J. Chao Umbilical Cord Blood: Biology and Transplantation Am. Assoc. Cancer Res. Educ. Book, April 1, 2006; 2006(1): 329 - 333. [Full Text] [PDF] K. K. Ballen New trends in umbilical cord blood transplantation Blood, May 15, 2005; 105(10): 3786 - 3792. [Abstract] [Full Text] [PDF] R. Bornstein, A. I. Flores, M. A. Montalban, M. J. del Rey, J. de la Serna, and F. Gilsanz A Modified Cord Blood Collection Method Achieves Sufficient Cell Levels for Transplantation in Most Adult Patients Stem Cells, March 1, 2005; 23(3): 324 - 334. [Abstract] [Full Text] [PDF] S. Takahashi, T. 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