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Blood, 15 January 2004, Vol. 103, No. 2, pp. 583-585.
Prepublished online as a Blood First Edition Paper on September 22, 2003; DOI 10.1182/blood-2003-08-2870.
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HEMATOPOIESIS
Brief report
Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development
Yuko Fujiwara,
Aaron N. Chang,
Aimée M. Williams, and
Stuart H. Orkin
From the Division of Hematology/Oncology, Children's Hospital and Dana Farber Cancer Institute; and Department of Pediatrics, Harvard Medical School and the Howard Hughes Medical Institute, Boston, MA.
Transcription factors GATA-1 and GATA-2 are required for normal hematopoiesis. The loss of either leads to embryonic lethality in knockout mice because of the failure of erythroid maturation and the expansion of progenitors, respectively. As the expression of GATA-1 and GATA-2 overlaps within hematopoietic progenitors, the extent to which these factors functionally compensate for each other during embryogenesis is unknown. As shown here, we have analyzed double-knockout embryos at the yolk sac stage of development and have shown that the combined absence of these GATA factors virtually ablates primitive erythroid cell formation. Thus, the function of GATA-1 and GATA-2 overlaps at the yolk sac stage. Moreover, a GATA factor, either GATA-1 or GATA-2, is required to initiate blood formation in the embryo.
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