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Blood, 15 January 2004, Vol. 103, No. 2, pp. 639-647. Prepublished online as a Blood First Edition Paper on September 22, 2003; DOI 10.1182/blood-2003-05-1707. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1707v1 103/2/639    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pitchford, S. C. Articles by Page, C. P. Search for Related Content PubMed PubMed Citation Articles by Pitchford, S. C. Articles by Page, C. P. Related Collections Hemostasis, Thrombosis, and Vascular Biology Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  IMMUNOBIOLOGY Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation Simon C. Pitchford, Yanira Riffo-Vasquez, Ana Sousa, Stefania Momi, Paolo Gresele, Domenico Spina, and Clive P. Page From the Sackler Institute of Pulmonary Pharmacology, GKT School of Biomedical Sciences, King's College London, United Kingdom; and the Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Italy. Asthma is associated with airway remodeling. Evidence of platelet recruitment to the lungs of asthmatics after allergen exposure suggests platelets participate in various aspects of asthma; although their importance is unknown in the context of airway remodeling, their involvement in atherosclerosis is established. Studies from our laboratory have shown a requirement for platelets in pulmonary leukocyte recruitment in a murine model of allergic lung inflammation. Presently, the effects of platelet depletion and corticosteroid administration on airway remodeling and lung function were examined. Ovalbumin (OVA)–sensitized mice, exposed to aerosolized OVA for 8 weeks, demonstrated epithelial and smooth muscle thickening, and subepithelial reticular fiber deposition in the distal airways. The depletion of platelets via an immunologic (antiplatelet antisera) or nonimmunologic (busulfan) method, markedly reduced airway remodeling. In contrast, dexamethasone administration did not affect epithelial thickening or subepithelial fibrosis, despite significantly inhibiting leukocyte recruitment. Thus, pathways leading to certain aspects of airway remodeling may not depend on leukocyte recruitment, whereas platelet activation is obligatory. OVA-sensitized mice exhibited airway hyperresponsiveness (AHR) compared with shamsensitized mice following chronic OVA exposure. Neither platelet depletion nor dexamethasone administration inhibited chronic AHR; thus, mechanisms other than inflammation and airway remodeling may be involved in the pathogenesis of chronic AHR. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. C. Pitchford, S. Momi, S. Baglioni, L. Casali, S. Giannini, R. Rossi, C. P. Page, and P. Gresele Allergen Induces the Migration of Platelets to Lung Tissue in Allergic Asthma Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 604 - 612. [Abstract] [Full Text] [PDF] Z. Li, R. E. Rumbaut, A. R. Burns, and C. W. Smith Platelet Response to Corneal Abrasion Is Necessary for Acute Inflammation and Efficient Re-epithelialization Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4794 - 4802. [Abstract] [Full Text] [PDF] N. M. Kushnir-Sukhov, A. M. Gilfillan, J. W. Coleman, J. M. Brown, S. Bruening, M. Toth, and D. D. Metcalfe 5-Hydroxytryptamine Induces Mast Cell Adhesion and Migration J. Immunol., November 1, 2006; 177(9): 6422 - 6432. [Abstract] [Full Text] [PDF] W. R. Henderson Jr., G. K. S. Chiang, Y.-t. Tien, and E. Y. Chi Reversal of Allergen-induced Airway Remodeling by CysLT1 Receptor Blockade Am. J. Respir. Crit. Care Med., April 1, 2006; 173(7): 718 - 728. [Abstract] [Full Text] [PDF] B. P. O'Sullivan and A. D. Michelson The Inflammatory Role of Platelets in Cystic Fibrosis Am. J. Respir. Crit. Care Med., March 1, 2006; 173(5): 483 - 490. [Abstract] [Full Text] [PDF] L. A. Moraes, M. J. Paul-Clark, A. Rickman, R. J. Flower, N. J. Goulding, and M. Perretti Ligand-specific glucocorticoid receptor activation in human platelets Blood, December 15, 2005; 106(13): 4167 - 4175. [Abstract] [Full Text] [PDF] M. Schmitt-Sody, A. Klose, O. Gottschalk, P. Metz, H. Gebhard, S. Zysk, M. E. Eichhorn, T. M. Hernandez-Richter, V. Jansson, and A. Veihelmann Platelet endothelial cell interactions in murine antigen-induced arthritis Rheumatology, July 1, 2005; 44(7): 885 - 889. [Abstract] [Full Text] [PDF] S. C. Pitchford, S. Momi, S. Giannini, L. Casali, D. Spina, C. P. Page, and P. Gresele Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation Blood, March 1, 2005; 105(5): 2074 - 2081. [Abstract] [Full Text] [PDF] F. Roviezzo, F. Del Galdo, G. Abbate, M. Bucci, B. D'Agostino, E. Antunes, G. De Dominicis, L. Parente, F. Rossi, G. Cirino, et al. Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate PNAS, July 27, 2004; 101(30): 11170 - 11175. [Abstract] [Full Text] [PDF]

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