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Blood, 15 January 2004, Vol. 103, No. 2, pp. 695-697. Prepublished online as a Blood First Edition Paper on September 11, 2003; DOI 10.1182/blood-2003-06-1901. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-06-1901v1 103/2/695    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhao, W.-L. Articles by Janin, A. Search for Related Content PubMed PubMed Citation Articles by Zhao, W.-L. Articles by Janin, A. Related Collections Neoplasia Apoptosis Oncogenes and Tumor Suppressors Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Brief report Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma Wei-Li Zhao, Marjan Ertault Daneshpouy, Nicolas Mounier, Josette Brière, Christophe Leboeuf, Louis-François Plassa, Elisabeth Turpin, Jean-Michel Cayuela, Jean-Claude Ameisen, Christian Gisselbrecht, and Anne Janin From the ERM-0220, Institut Universitaire d'Hématologie, Université Paris VII, Hôpital Saint-Louis, Paris; Service de Biochimie B and CNRS UPR-9051, Hôpital Saint-Louis, Paris; Institut National de la Santé et de la Recherche Médicale (INSERM) U462, Laboratoire d'Hématologie, Hôpital Saint-Louis, Paris; and EMI-U 9922 INSERM/Université Paris VII, IFR 02, Hôpital Bichat-Claude-Bernard, Paris, France. bcl-xL, a member of the Bcl-2 family, exerts an antiapoptotic effect on lymphocytes. To assess its clinical significance in patients with follicular lymphoma, realtime quantitative reverse transcription–polymerase chain reaction (RT-PCR) analysis of bcl-xL gene expression was investigated in whole lymph node sections and laser-microdissected lymphoma cells of 27 patients. Compared with 10 patients with reactive follicular hyperplasia, the bcl-xL gene was overexpressed in patients with follicular lymphoma at a higher level in microdissected lymphoma cells. The bcl-xL gene level correlated with the number of apoptotic lymphoma cells labeled by terminal deoxytransferase-catalyzed DNA nick-end labeling (TUNEL) assays (r = -0.7736). Clinically, a high bcl-xL level was significantly associated with multiple sites of extranodal involvement (P = .0020), elevated lactate dehydrogenase level (P = .0478), and an International Prognostic Index indicating high risk (P = .0235). Moreover, bcl-xL gene overexpression was linked to short overall survival times (P = .0129). The value of bcl-xL gene expression as a prognostic marker in follicular lymphoma should thus be considered. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. Dornan, F. Bennett, Y. Chen, M. Dennis, D. Eaton, K. Elkins, D. French, M. A. T. Go, A. Jack, J. R. Junutula, et al. Therapeutic potential of an anti-CD79b antibody-drug conjugate, anti-CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma Blood, September 24, 2009; 114(13): 2721 - 2729. [Abstract] [Full Text] [PDF] D. Kerob, F. Pedeutour, C. Leboeuf, O. Verola, E. de Kerviler, J. M. Servant, F. Sarandi, G. Bousquet, I. Madelaine-Chambrin, C. Pruvost, et al. Value of Cytogenetic Analysis in the Treatment of Dermatofibrosarcoma Protuberans J. Clin. Oncol., April 1, 2008; 26(10): 1757 - 1759. [Full Text] [PDF] D. Canioni, G. Salles, N. Mounier, N. Brousse, M. Keuppens, F. Morchhauser, T. Lamy, A. Sonet, M.-C. Rousselet, C. Foussard, et al. 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