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Blood, 15 January 2004, Vol. 103, No. 2, pp. 740-742. Prepublished online as a Blood First Edition Paper on September 22, 2003; DOI 10.1182/blood-2003-05-1500. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1500v1 103/2/740    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Milinkovic, M. Articles by Sackstein, R. Search for Related Content PubMed PubMed Citation Articles by Milinkovic, M. Articles by Sackstein, R. Related Collections Transplantation Cell Adhesion and Motility Brief Reports Hemostasis, Thrombosis, and Vascular Biology Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Brief report CD44-hyaluronic acid interactions mediate shear-resistant binding of lymphocytes to dermal endothelium in acute cutaneous GVHD Mirjana Milinkovic, Joseph H. Antin, Charles A. Hergrueter, Charles B. Underhill, and Robert Sackstein From the Departments of Dermatology, Medicine, and Surgery, Brigham and Women's Hospital, Boston; the Harvard Skin Disease Research Center, Harvard Medical School, Boston; the Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; and the Department of Oncology, School of Medicine, Georgetown University, Washington, DC. For circulating lymphocytes to migrate to inflammatory sites, they must first adhere to the target tissue endothelium with sufficient strength to overcome the shear forces of blood flow. We previously reported that dermal papillary vessels in acute graft-versus-host disease (aGVHD) support shear-resistant lymphocyte adherence. We now identify the relevant adhesion molecule(s) directing this binding, showing that interactions between lymphocyte CD44 and hyaluronic acid (HA) expressed on dermal vessels in aGVHD alone confer this shear-resistant attachment. Native HA deposits on vascular endothelium support lymphocyte adherence, whereas HA immobilized on plastic does not. HA expressed at dermal endothelium in aGVHD is thus specialized to support lymphocyte adherence under flow conditions, and CD44-HA interactions may contribute to lymphocytotropism to skin in aGVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Misra, L. M. Obeid, Y. A. Hannun, S. Minamisawa, F. G. Berger, R. R. Markwald, B. P. Toole, and S. Ghatak Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells J. Biol. Chem., May 23, 2008; 283(21): 14335 - 14344. [Abstract] [Full Text] [PDF] M. S. Hossain, J. D. Roback, B. P. Pollack, D. L. Jaye, A. Langston, and E. K. Waller Chronic GvHD decreases antiviral immune responses in allogeneic BMT Blood, May 15, 2007; 109(10): 4548 - 4556. [Abstract] [Full Text] [PDF] L. Zhuo, A. Kanamori, R. Kannagi, N. Itano, J. Wu, M. Hamaguchi, N. Ishiguro, and K. Kimata SHAP Potentiates the CD44-mediated Leukocyte Adhesion to the Hyaluronan Substratum J. Biol. Chem., July 21, 2006; 281(29): 20303 - 20314. [Abstract] [Full Text] [PDF] M. M. Burdick, J. T. Chu, S. Godar, and R. Sackstein HCELL Is the Major E- and L-selectin Ligand Expressed on LS174T Colon Carcinoma Cells J. Biol. Chem., May 19, 2006; 281(20): 13899 - 13905. [Abstract] [Full Text] [PDF] J. M. Zmolik and M. E. Mummert Pep-1 as a Novel Probe for the In Situ Detection of Hyaluronan J. Histochem. Cytochem., June 1, 2005; 53(6): 745 - 751. [Abstract] [Full Text] [PDF]

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