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Blood, 1 February 2004, Vol. 103, No. 3, pp. 1043-1049. Prepublished online as a Blood First Edition Paper on October 2, 2003; DOI 10.1182/blood-2003-05-1518. This Article Full Text Full Text (PDF) Supplemental Tables All Versions of this Article: 2003-05-1518v1 103/3/1043    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fine, B. M. Articles by Boxer, L. M. Search for Related Content PubMed PubMed Citation Articles by Fine, B. M. Articles by Boxer, L. M. Related Collections Hematopoiesis and Stem Cells Neoplasia Oncogenes and Tumor Suppressors Gene Expression Genomics Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  NEOPLASIA Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia Bernard M. Fine, Martin Stanulla, Martin Schrappe, Minh Ho, Susanne Viehmann, Jochen Harbott, and Linda M. Boxer From the Center for Molecular Biology in Medicine, VA Palo Alto Health Care System, Palo Alto, CA, and Department of Medicine, Stanford University School of Medicine, Palo Alto, CA; Department of Biochemistry and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA; Department of Pediatric Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany; and the Oncogenetic Laboratory, Children's University Hospital, Giessen, Germany. We obtained a global view of gene expression in both cell lines and pediatric acute lymphoblastic leukemia (ALL) samples that harbor one of several selected chromosomal abnormalities. When the cell lines were studied alone, we found that these chromosomal abnormalities were associated with the predominant variation in transcriptional programs across the set of cell lines studied. When cell lines and clinical samples were studied together, we found that each chromosomal abnormality (TEL/AML1, BCR/ABL, or MLL abnormalities) was associated with a characteristic gene expression signature that was shared by both cell lines and clinical samples. However, BCR/ABL was associated with a much more heterogeneous pattern of expression than were TEL/AML1 and MLL abnormalities. This observation has important implications for the study of BCR/ABL ALL. In addition, we systematically identified genes whose expression was associated with TEL/AML1, BCR/ABL, or MLL abnormalities in both clinical samples and cell lines. Although some of these genes have previously been described, many have not previously been reported to be associated with one of these chromosomal abnormalities. Notably, we found that the erythropoietin receptor (EPOR) is consistently highly expressed in TEL/AML1 ALL compared with BCR/ABL or MLL. (Blood. 2004;103:1043-1049) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Argiropoulos, E. Yung, and R. K. Humphries Unraveling the crucial roles of Meis1 in leukemogenesis and normal hematopoiesis Genes & Dev., November 15, 2007; 21(22): 2845 - 2849. [Full Text] [PDF] G. Cario, S. Izraeli, A. Teichert, P. Rhein, J. Skokowa, A. Moricke, M. Zimmermann, A. Schrauder, L. Karawajew, W.-D. Ludwig, et al. 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