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Blood, 1 February 2004, Vol. 103, No. 3, pp. 860-867. Prepublished online as a Blood First Edition Paper on October 2, 2003; DOI 10.1182/blood-2003-04-1160. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-04-1160v1 103/3/860    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kambe, N. Articles by Nakahata, T. Search for Related Content PubMed PubMed Citation Articles by Kambe, N. Articles by Nakahata, T. Related Collections Hematopoiesis and Stem Cells Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body Naotomo Kambe, Hidefumi Hiramatsu, Mika Shimonaka, Hisanori Fujino, Ryuta Nishikomori, Toshio Heike, Mamoru Ito, Kimio Kobayashi, Yoshito Ueyama, Norihisa Matsuyoshi, Yoshiki Miyachi, and Tatsutoshi Nakahata From the Department of Pediatrics and Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Central Institute for Experimental Animals, Kawasaki, Japan; and the Department of Pathology, Tokai University School of Medicine, Isehara, Japan. The transplantation of primitive human cells into sublethally irradiated immune-deficient mice is the well-established in vivo system for the investigation of human hematopoietic stem cell function. Although mast cells are the progeny of hematopoietic stem cells, human mast cell development in mice that underwent human hematopoietic stem cell transplantation has not been reported. Here we report on human mast cell development after xenotransplantation of human hematopoietic stem cells into nonobese diabetic severe combined immunodeficient (NOG) mice with severe combined immunodeficiency and interleukin 2 (IL-2) receptor -chain allelic mutation. Supported by the murine environment, human mast cell clusters developed in mouse dermis, but they required more time than other forms of human cell reconstitution. In lung and gastric tract, mucosal-type mast cells containing tryptase but lacking chymase located on gastric mucosa and in alveoli, whereas connective tissue-type mast cells containing both tryptase and chymase located on gastric submucosa and around major airways, as in the human body. Mast cell development was also observed in lymph nodes, spleen, and peritoneal cavity but not in the peripheral blood. Xenotransplantation of human hematopoietic stem cells into NOG mice can be expected to result in a highly effective model for the investigation of human mast cell development and function in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Nakamura, N. Kambe, M. Saito, R. Nishikomori, Y.-G. Kim, M. Murakami, G. Nunez, and H. Matsue Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria J. Exp. 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D'Ambrosio VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3 J. Leukoc. Biol., January 1, 2007; 81(1): 250 - 262. [Abstract] [Full Text] [PDF] F. Schiemann, T. A. Grimm, J. Hoch, R. Gross, B. Lindner, F. Petersen, S. Bulfone-Paus, and E. Brandt Mast cells and neutrophils proteolytically activate chemokine precursor CTAP-III and are subject to counterregulation by PF-4 through inhibition of chymase and cathepsin G Blood, March 15, 2006; 107(6): 2234 - 2242. [Abstract] [Full Text] [PDF] J. R. Timoshanko, R. Kitching, T. J. Semple, P. G. Tipping, and S. R. Holdsworth A Pathogenetic Role for Mast Cells in Experimental Crescentic Glomerulonephritis J. Am. Soc. Nephrol., January 1, 2006; 17(1): 150 - 159. [Abstract] [Full Text] [PDF] J. Sawada, S. Shimizu, T. Tamatani, S. Kanegasaki, H. Saito, A. Tanaka, N. Kambe, T. Nakahata, and H. Matsuda Stem Cell Factor Has a Suppressive Activity to IgE-Mediated Chemotaxis of Mast Cells J. 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