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Blood, 1 February 2004, Vol. 103, No. 3, pp. 963-965. Prepublished online as a Blood First Edition Paper on October 30, 2003; DOI 10.1182/blood-2003-05-1502. This Article Full Text Full Text (PDF) Supplemental Table All Versions of this Article: 2003-05-1502v1 103/3/963    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Afshar-Kharghan, V. Articles by López, J. A. Search for Related Content PubMed PubMed Citation Articles by Afshar-Kharghan, V. Articles by López, J. A. Related Collections Hemostasis, Thrombosis, and Vascular Biology Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Brief report The variable number of tandem repeat polymorphism of platelet glycoprotein Ib and risk of coronary heart disease Vahid Afshar-Kharghan, Nevenka Matijevic-Aleksic, Chul Ahn, Eric Boerwinkle, Kenneth K. Wu, and José A. López From the Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, TX; and University of Texas at Houston Health Science Center, Houston. Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ib, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ib and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ib is different among whites and African Americans. The B allele (with 3 repeats) of GP Ib is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes. (Blood. 2004;103:963-965) CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. E. Breslow, T. Lumley, C. M. Ballantyne, L. E. Chambless, and M. Kulich Using the Whole Cohort in the Analysis of Case-Cohort Data Am. J. Epidemiol., June 1, 2009; 169(11): 1398 - 1405. [Abstract] [Full Text] [PDF] S.-Z. Luo, X. Mo, V. Afshar-Kharghan, S. Srinivasan, J. A. Lopez, and R. Li Glycoprotein Ib{alpha} forms disulfide bonds with 2 glycoprotein Ib{beta} subunits in the resting platelet Blood, January 15, 2007; 109(2): 603 - 609. [Abstract] [Full Text] [PDF] H Douglas, G J Davies, K Michaelides, D A Gorog, H Timlin, N Ahmed, and E G D Tuddenham Detection of functional differences between different platelet membrane glycoprotein Ibalpha variable number tandem repeat and Kozak genotypes as shown by the PFA-100 system. Heart, May 1, 2006; 92(5): 676 - 678. [Full Text] [PDF]

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