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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1521-1526. Prepublished online as a Blood First Edition Paper on September 22, 2003; DOI 10.1182/blood-2003-02-0438. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-02-0438v1 103/4/1521    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cook, M. A. Articles by Briggs, D. C. Search for Related Content PubMed PubMed Citation Articles by Cook, M. A. Articles by Briggs, D. C. Related Collections Immunobiology Transplantation Immunotherapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia Mark A. Cook, Donald W. Milligan, Christopher D. Fegan, Philip J. Darbyshire, Premini Mahendra, Charles F. Craddock, Paul A. H. Moss, and David C. Briggs From the Cancer Research United Kingdom (CRC) Institute for Cancer Studies, University of Birmingham; the Department of Histocompatibility & Immunogenetics, National Blood Service; the Department of Haematology, University Hospital Birmingham National Health Service (NHS) Trust; the Department of Haematology, Birmingham Heartlands & Solihull NHS Trust; and the Department of Haematology, Birmingham Children's Hospital NHS Trust, Birmingham, United Kingdom. Killer immunoglobulin–like receptors (KIRs) regulate cell activity of natural killer (NK) cells and some T cells. The predominant ligand for inhibitory KIRs is HLA-C, which subdivides into 2 groups based on the specificity of inhibitory KIRs. The ligands for activatory KIRs are unknown. Following hematopoietic stem cell transplantation (HSCT), recipient tissues may not express a ligand for KIRs present within the graft, and the combination of donor KIR and recipient HLA-C types could influence outcome. HLA and KIR genotypes were determined in 220 donor-recipient pairs from HLA-matched sibling HSCTs performed for myeloid (n = 112) and lymphoid (n = 108) diseases. In HSCTs performed for myeloid disease, overall survival was worse in patients homozygous for group 2 HLA-C (C2) than in patients who carried a group 1 HLA-C (C1) allele (P < .005). Moreover, this effect is seen only when the donor additionally carries the activating KIR gene KIR2DS2 (P = .045). No effect was seen in patients with lymphoid disease. Thus, in HLA-matched sibling HSCT for myeloid leukemia, patients homozygous for C2 alleles receiving a graft from a donor carrying the KIR gene KIR2DS2 have a significantly reduced chance of survival. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Cooley, E. Trachtenberg, T. L. Bergemann, K. Saeteurn, J. Klein, C. T. Le, S. G. E. Marsh, L. A. Guethlein, P. Parham, J. S. Miller, et al. Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia Blood, January 15, 2009; 113(3): 726 - 732. [Abstract] [Full Text] [PDF] J. H. Chewning, C. N. Gudme, K. C. Hsu, A. Selvakumar, and B. Dupont KIR2DS1-Positive NK Cells Mediate Alloresponse against the C2 HLA-KIR Ligand Group In Vitro J. Immunol., July 15, 2007; 179(2): 854 - 868. [Abstract] [Full Text] [PDF] J. C. 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Dupont Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes Blood, June 15, 2005; 105(12): 4878 - 4884. [Abstract] [Full Text] [PDF] S. J. Lee New approaches for preventing and treating chronic graft-versus-host disease Blood, June 1, 2005; 105(11): 4200 - 4206. [Abstract] [Full Text] [PDF] W. Leung, R. Iyengar, B. Triplett, V. Turner, F. G. Behm, M. S. Holladay, J. Houston, and R. Handgretinger Comparison of Killer Ig-Like Receptor Genotyping and Phenotyping for Selection of Allogeneic Blood Stem Cell Donors J. Immunol., May 15, 2005; 174(10): 6540 - 6545. [Abstract] [Full Text] [PDF] S. E. Hiby, J. J. Walker, K. M. O'Shaughnessy, C. W.G. Redman, M. Carrington, J. Trowsdale, and A. Moffett Combinations of Maternal KIR and Fetal HLA-C Genes Influence the Risk of Preeclampsia and Reproductive Success J. Exp. Med., October 18, 2004; 200(8): 957 - 965. [Abstract] [Full Text] [PDF] M. Bornhauser, R. Schwerdtfeger, H. Martin, K.-H. Frank, C. Theuser, G. Ehninger, F. Locatelli, A. Velardi, and S. Giebel Role of KIR ligand incompatibility in hematopoietic stem cell transplantation using unrelated donors Blood, April 1, 2004; 103(7): 2860 - 2861. [Full Text] [PDF]

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