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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1534-1541. Prepublished online as a Blood First Edition Paper on October 9, 2003; DOI 10.1182/blood-2003-08-2987. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-08-2987v1 103/4/1534    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chen, B. J. Articles by Chao, N. J. Search for Related Content PubMed PubMed Citation Articles by Chen, B. J. Articles by Chao, N. J. Related Collections Immunobiology Transplantation Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Transfer of allogeneic CD62L– memory T cells without graft-versus-host disease Benny J. Chen, Xiuyu Cui, Gregory D. Sempowski, Congxiao Liu, and Nelson J. Chao From the Bone Marrow Transplantation Program, Departments of Medicine and Immunology, Human Vaccine Institute, Duke University Medical Center, Durham, NC. The major challenge in allogeneic hematopoietic cell transplantation is how to transfer allogeneic T-cell immunity without causing graft-versus-host disease (GVHD). Here we report a novel strategy to selectively prevent GVHD by depleting CD62L+ T cells (naive and a subset of memory T cells). In unprimed mice, CD62L– T cells (a subset of memory T cells) failed to proliferate in response to alloantigens (which the mice have never previously encountered) and were unable to induce GVHD in allogeneic hosts. CD62L– T cells contributed to T-cell reconstitution by peripheral expansion as well as by promoting T-cell regeneration from bone marrow stem/progenitor cells. CD62L– T cells from the animals previously primed with a tumor cell line (BCL1) were able to inhibit the tumor growth in vivo but were unable to induce GVHD in the third-party recipients. This novel technology may allow transfer of allogeneic recall antitumor and antimicrobial immunity without causing GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Bohana-Kashtan, S. Morisot, R. Hildreth, C. Brayton, H. I. Levitsky, and C. I. Civin Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand J. Immunol., July 1, 2009; 183(1): 696 - 705. [Abstract] [Full Text] [PDF] H. Zheng, C. Matte-Martone, D. Jain, J. McNiff, and W. D. 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Shlomchik, and M. J. Shlomchik Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells Blood, May 15, 2008; 111(10): 5242 - 5251. [Abstract] [Full Text] [PDF] H. Zheng, C. Matte-Martone, H. Li, B. E. Anderson, S. Venketesan, H. Sheng Tan, D. Jain, J. McNiff, and W. D. Shlomchik Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease Blood, February 15, 2008; 111(4): 2476 - 2484. [Abstract] [Full Text] [PDF] Y. Liang, C. Liu, J. Y. Djeu, B. Zhong, T. Peters, K. Scharffetter-Kochanek, C. Anasetti, and X.-Z. Yu 2 integrins separate graft-versus-host disease and graft-versus-leukemia effects Blood, January 15, 2008; 111(2): 954 - 962. [Abstract] [Full Text] [PDF] S. Dutt, D. Tseng, J. Ermann, T. I. George, Y. P. Liu, C. R. Davis, C. G. Fathman, and S. Strober Naive and Memory T Cells Induce Different Types of Graft-versus-Host Disease J. 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