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Blood, 1 March 2004, Vol. 103, No. 5, pp. 1580-1585. Prepublished online as a Blood First Edition Paper on November 6, 2003; DOI 10.1182/blood-2003-05-1595. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-05-1595v1 103/5/1580    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Papayannopoulou, T. Search for Related Content PubMed PubMed Citation Articles by Papayannopoulou, T. Related Collections Perspectives Hematopoiesis and Stem Cells Cell Adhesion and Motility Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  PERSPECTIVES Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization Thalia Papayannopoulou From the University of Washington, Seattle, WA. Abstract Uncovering the molecular mechanisms governing the exit of stem/progenitor cells from bone marrow to peripheral blood at steady state or after their enforced migration has been an ongoing challenge. Recently, however, several new avenues or paradigms in mobilization have emerged from ever-expanding work in humans subjected to granulocyte colony-stimulating factor (G-CSF) mobilization, as well as from studies in normal and gene-deficient mouse models. Although these developments represent notable advances that met with considerable excitement, they have been quenched by surprising vacillations in subsequent research. This perspective highlights recent developments in mobilization along with their controversies. A full understanding of the directional cues that control the migratory behavior and the fate of stem/progenitor cells once they migrate out of bone marrow will await further experimentation, aiming to bridge our current gaps in knowledge. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Spiegel, E. Zcharia, Y. Vagima, T. Itkin, A. Kalinkovich, A. Dar, O. Kollet, N. Netzer, K. Golan, I. Shafat, et al. Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment Blood, May 15, 2008; 111(10): 4934 - 4943. [Abstract] [Full Text] [PDF] T. Papayannopoulou and D. T. 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