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Blood, 1 March 2004, Vol. 103, No. 5, pp. 1728-1734. Prepublished online as a Blood First Edition Paper on November 13, 2003; DOI 10.1182/blood-2003-08-2886. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-08-2886v1 103/5/1728    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kerlin, B. Articles by Weiler, H. Search for Related Content PubMed PubMed Citation Articles by Kerlin, B. Articles by Weiler, H. Related Collections Hemostasis, Thrombosis, and Vascular Biology Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Cause-effect relation between hyperfibrinogenemia and vascular disease Bryce Kerlin, Brian C. Cooley, Berend H. Isermann, Irene Hernandez, Rashmi Sood, Mark Zogg, Sara B. Hendrickson, Michael W. Mosesson, Susan Lord, and Hartmut Weiler From the Blood Research Institute, Blood Center of SE Wisconsin, Milwaukee; Medical College of Wisconsin, Milwaukee; University of North Carolina at Chapel Hill. Elevated plasma levels of fibrinogen are associated with the presence of cardiovascular disease, but it is controversial whether elevated fibrinogen causally imparts an increased risk, and as such is a true modifier of cardiovascular disease, or is merely associated with disease. By investigating a transgenic mouse model of hyperfibrinogenemia, we show that elevated plasma fibrinogen concentration (1) elicits augmented fibrin deposition in specific organs, (2) interacts with an independent modifier of hemostatic activity to regulate fibrin turnover/deposition, (3) exacerbates neointimal hyperplasia in an experimental model of stasis-induced vascular remodeling, yet (4) may suppress thrombin generation in response to a procoagulant challenge. These findings provide direct experimental evidence that hyperfibrinogenemia is more than a by-product of cardiovascular disease and may function independently or interactively to modulate the severity and/or progression of vascular disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Hyperfibrinogenemia and vascular disease: does it matter? William P. Fay Blood 2004 103: 1569-1570. [Full Text] [PDF] This article has been cited by other articles: J. C. Fredenburgh, A. R. Stafford, B. A. Leslie, and J. I. Weitz Bivalent Binding to {gamma}A/{gamma}'-Fibrin Engages Both Exosites of Thrombin and Protects It from Inhibition by the Antithrombin-Heparin Complex J. Biol. Chem., February 1, 2008; 283(5): 2470 - 2477. [Abstract] [Full Text] [PDF] E. J. Kerschen, J. A. Fernandez, B. C. Cooley, X. V. Yang, R. Sood, L. O. Mosnier, F. J. Castellino, N. Mackman, J. H. Griffin, and H. Weiler Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C J. Exp. Med., October 1, 2007; 204(10): 2439 - 2448. [Abstract] [Full Text] [PDF] W. P. Fay, N. Garg, and M. Sunkar Vascular Functions of the Plasminogen Activation System Arterioscler. Thromb. Vasc. Biol., June 1, 2007; 27(6): 1231 - 1237. [Abstract] [Full Text] [PDF] S. Mora, N. Rifai, J. E. Buring, and P. M Ridker Additive Value of Immunoassay-Measured Fibrinogen and High-Sensitivity C-Reactive Protein Levels for Predicting Incident Cardiovascular Events Circulation, August 1, 2006; 114(5): 381 - 387. [Abstract] [Full Text] [PDF] T. Iwaki, M. J. Sandoval-Cooper, M. Brechmann, V. A. Ploplis, and F. J. Castellino A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice Blood, May 15, 2006; 107(10): 3883 - 3891. [Abstract] [Full Text] [PDF] N. Mackman Tissue-Specific Hemostasis in Mice Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): 2273 - 2281. [Abstract] [Full Text] [PDF] H. Yamashita, J. Kitayama, and H. Nagawa Hyperfibrinogenemia is a Useful Predictor for Lymphatic Metastasis in Human Gastric Cancer Jpn. J. Clin. Oncol., October 1, 2005; 35(10): 595 - 600. [Abstract] [Full Text] [PDF] A. B. Maulaz, D. C. Bezerra, P. Michel, and J. Bogousslavsky Effect of Discontinuing Aspirin Therapy on the Risk of Brain Ischemic Stroke Arch Neurol, August 1, 2005; 62(8): 1217 - 1220. [Abstract] [Full Text] [PDF] F. Tuluc, A. Garcia, O. Bredetean, J. Meshki, and S. P. Kunapuli Primary granule release from human neutrophils is potentiated by soluble fibrinogen through a mechanism depending on multiple intracellular signaling pathways Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1264 - C1272. [Abstract] [Full Text] [PDF] E. M. Scott, R. A.S. Ariens, and P. J. Grant Genetic and Environmental Determinants of Fibrin Structure and Function: Relevance to Clinical Disease Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1558 - 1566. [Abstract] [Full Text] [PDF]

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